| Literature DB >> 29253952 |
Zheng Gao1, Chen Zhang1, Chengye Tian2, Zhenzhen Ren1, Xinling Song1, Xiuxiu Wang1, Nuo Xu1, Huijuan Jing1, Shangshang Li1, Weiru Liu3, Jianjun Zhang4, Le Jia5.
Abstract
The present work investigated the characteristics, antioxidative, anti-inflammative and renoprotective effects of mycelia selenized polysaccharides (MSPS) from Oudemansiella radicata on lipopolysaccharide (LPS)-induced kidney damaged mice. The results demonstrated that both MSPS and mycelia polysaccharides (MPS) showed potential renoprotective effects reflecting by decreasing the serum levels of CRE, BUN and UA, increasing the nephritic enzyme activities of SOD, GSH-Px, CAT and T-AOC, reducing the activities of MPO, as well as down-regulating the contents of MDA and LPO, respectively. And the MSPS showed superior effects. Furthermore, the selenium contents and physical properties of polysaccharides were investigated by FAAS, GC, HPGPC, FT-IR, NMR and AFM analysis, and the results indicated that MSPS was a homogeneous heteropolysaccharide with an average molecular weight of 3.12×104Da. These results may provide theoretical basis in applying natural and functional foods for the prevention and alleviation of kidney damages and its complications.Entities:
Keywords: Anti-inflammation; Antioxidative effects; Oudemansiella radicata; Renoprotective effects; Selenium polysaccharides
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Year: 2017 PMID： 29253952 DOI： 10.1016/j.carbpol.2017.12.007
Source DB: PubMed Journal: Carbohydr Polym ISSN： 0144-8617 Impact factor: 9.381