CASE: Giant cell tumor (GCT) of bone was first described almost 200 years ago, but the optimal treatment continues to evolve. We present a patient with a pelvic GCT who was treated with embolization, 20 months of denosumab therapy, and resection. Histologically, the tumor consisted of degenerated GCT, bone, and fibrous tissue. After 7 months, the patient was found to have osteosarcoma at the site of the initial lesion as well as pulmonary metastases. CONCLUSION: The apparent malignant transformation of a GCT of bone treated initially with denosumab indicates that close follow-up is warranted.
CASE: Giant cell tumor (GCT) of bone was first described almost 200 years ago, but the optimal treatment continues to evolve. We present a patient with a pelvic GCT who was treated with embolization, 20 months of denosumab therapy, and resection. Histologically, the tumor consisted of degenerated GCT, bone, and fibrous tissue. After 7 months, the patient was found to have osteosarcoma at the site of the initial lesion as well as pulmonary metastases. CONCLUSION: The apparent malignant transformation of a GCT of bone treated initially with denosumab indicates that close follow-up is warranted.
Authors: Raphaële Charest-Morin; Charles G Fisher; Arjun Sahgal; Stefano Boriani; Ziya L Gokaslan; Aron Lazary; Jeremy Reynolds; Chetan Bettegowda; Laurence D Rhines; Nicolas Dea Journal: Global Spine J Date: 2019-05-08
Authors: Marc Hasenfratz; Kevin Mellert; Ralf Marienfeld; Alexandra von Baer; Markus Schultheiss; P D Roitman; L A Aponte-Tinao; Burkhard Lehner; Peter Möller; Gunhild Mechtersheimer; Thomas F E Barth Journal: Sci Rep Date: 2021-03-11 Impact factor: 4.379
Authors: Michael D Eckhoff; Matthew E Wells; Osvaldo Padilla; Elizabeth M Polfer; Christopher J Castagno; Ahmed M Thabet; Shaimaa Elzamly; Harry L Wilson; Rajiv Rajani Journal: J Am Acad Orthop Surg Glob Res Rev Date: 2022-10-13