Ishaq Ibrahim1, Bryan D Haughom2, Yale A Fillingham2, Nicholas Brown2, Steven Gitelis2. 1. Rush University School of Medicine, 600 South Paulina Street, Chicago, IL 60612. E-mail address: iibrahim005@gmail.com. 2. Department of Orthopaedic Surgery, Rush University, 1611 West Harrison Boulevard, Suite 200, Chicago, IL 60612. E-mail address for B.D. Haughom: bryan.haughom@gmail.com. E-mail address for Y.A. Fillingham: yale.fillingham@gmail.com. E-mail address for N. Brown: nmb2116@gmail.com. E-mail address for S. Gitelis: Steven_Gitelis@rush.edu.
Abstract
CASE: Primary lymphoma of bone is a rare musculoskeletal malignancy that typically arises in long bones. Few cases of bone lymphoma occurring alongside orthopaedic implants have been reported in the literature. We describe the complex case of a seventy-eight-year-old woman who developed diffuse large B-cell lymphoma of the proximal part of the tibia five years after a successful total knee arthroplasty. CONCLUSION: Several studies have suggested a link between orthopaedic implants and genomic instability, although true carcinogenesis remains questionable. Lymphoma complicating joint arthroplasty poses a unique problem for orthopaedic physicians due to diagnostic challenges and the unique implications of disease and treatment-related complications.
CASE: Primary lymphoma of bone is a rare musculoskeletal malignancy that typically arises in long bones. Few cases of bone lymphoma occurring alongside orthopaedic implants have been reported in the literature. We describe the complex case of a seventy-eight-year-old woman who developed diffuse large B-cell lymphoma of the proximal part of the tibia five years after a successful total knee arthroplasty. CONCLUSION: Several studies have suggested a link between orthopaedic implants and genomic instability, although true carcinogenesis remains questionable. Lymphoma complicating joint arthroplasty poses a unique problem for orthopaedic physicians due to diagnostic challenges and the unique implications of disease and treatment-related complications.