Literature DB >> 29252117

Live Attenuated Influenza Vaccines engineered to express the nucleoprotein of a recent isolate stimulate human influenza CD8+ T cells more relevant to current infections.

D Korenkov1,2, T H O Nguyen2, I Isakova-Sivak1, T Smolonogina1, L E Brown2, K Kedzierska2, L Rudenko1.   

Abstract

Live attenuated influenza vaccines (LAIV) induce CD8+ T lymphocyte responses that play an important role in killing virus-infected cells. Despite the relative conservation of internal influenza A proteins, the epitopes recognized by T cells can undergo drift under immune pressure. The internal proteins of Russian LAIVs are derived from the master donor virus A/Leningrad/134/17/57 (Len/17) isolated 60 years ago and as such, some CD8+ T cell epitopes may vary between the vaccine and circulating wild-type strains. To partially overcome this issue, the nucleoprotein (NP) gene of wild-type virus can be incorporated into LAIV reassortant virus, along with the HA and NA genes. The present study compares the human CD8+ T cell memory responses to H3N2 LAIVs with the Len/17 or the wild-type NP using an in vitro model.

Entities:  

Keywords:  Antigenic escape; LAIV; T cell epitope; influenza; nucleoprotein

Mesh：

Substances：

Year:  2018        PMID： 29252117      PMCID： PMC5893192          DOI： 10.1080/21645515.2017.1417713

Source DB:  PubMed          Journal:  Hum Vaccin Immunother        ISSN： 2164-5515            Impact factor:   3.452


  25 in total

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Authors:  N J Beekman; P A van Veelen; T van Hall; A Neisig; A Sijts; M Camps; P M Kloetzel; J J Neefjes; C J Melief; F Ossendorp
Journal:  J Immunol       Date:  2000-02-15       Impact factor: 5.422

2.  Positive Selection in CD8+ T-Cell Epitopes of Influenza Virus Nucleoprotein Revealed by a Comparative Analysis of Human and Swine Viral Lineages.

Authors:  Heather M Machkovech; Trevor Bedford; Marc A Suchard; Jesse D Bloom
Journal:  J Virol       Date:  2015-08-26       Impact factor: 5.103

3.  Acute emergence and reversion of influenza A virus quasispecies within CD8+ T cell antigenic peptides.

Authors:  Sophie A Valkenburg; Sergio Quiñones-Parra; Stephanie Gras; Naomi Komadina; Jodie McVernon; Zhongfang Wang; Hanim Halim; Pina Iannello; Catherine Cole; Karen Laurie; Anne Kelso; Jamie Rossjohn; Peter C Doherty; Stephen J Turner; Katherine Kedzierska
Journal:  Nat Commun       Date:  2013       Impact factor: 14.919

4.  Comparative studies of infectivity, immunogenicity and cross-protective efficacy of live attenuated influenza vaccines containing nucleoprotein from cold-adapted or wild-type influenza virus in a mouse model.

Authors:  Irina Isakova-Sivak; Daniil Korenkov; Tatiana Smolonogina; Tatiana Tretiak; Svetlana Donina; Andrey Rekstin; Anatoly Naykhin; Svetlana Shcherbik; Nicholas Pearce; Li-Mei Chen; Tatiana Bousse; Larisa Rudenko
Journal:  Virology       Date:  2016-11-06       Impact factor: 3.616

5.  Cross-reactive CD8+ T-cell immunity between the pandemic H1N1-2009 and H1N1-1918 influenza A viruses.

Authors:  Stephanie Gras; Lukasz Kedzierski; Sophie A Valkenburg; Karen Laurie; Yu Chih Liu; Justin T Denholm; Michael J Richards; Guus F Rimmelzwaan; Anne Kelso; Peter C Doherty; Stephen J Turner; Jamie Rossjohn; Katherine Kedzierska
Journal:  Proc Natl Acad Sci U S A       Date:  2010-06-28       Impact factor: 11.205

6.  Identification of broad binding class I HLA supertype epitopes to provide universal coverage of influenza A virus.

Authors:  Jeff Alexander; Pamuk Bilsel; Marie-France del Guercio; Aleksandra Marinkovic-Petrovic; Scott Southwood; Stephani Stewart; Glenn Ishioka; Maya F Kotturi; Jason Botten; John Sidney; Mark Newman; Alessandro Sette
Journal:  Hum Immunol       Date:  2010-03-10       Impact factor: 2.850

7.  Evolution in health and medicine Sackler colloquium: The comparative genomics of viral emergence.

Authors:  Edward C Holmes
Journal:  Proc Natl Acad Sci U S A       Date:  2009-10-26       Impact factor: 11.205

8.  Mapping the antigenic and genetic evolution of influenza virus.

Authors:  Derek J Smith; Alan S Lapedes; Jan C de Jong; Theo M Bestebroer; Guus F Rimmelzwaan; Albert D M E Osterhaus; Ron A M Fouchier
Journal:  Science       Date:  2004-06-24       Impact factor: 47.728

Review 9.  Influenza virus-specific cytotoxic T lymphocytes: a correlate of protection and a basis for vaccine development.

Authors:  Guus F Rimmelzwaan; Ron A M Fouchier; Albert D M E Osterhaus
Journal:  Curr Opin Biotechnol       Date:  2007-12       Impact factor: 9.740

10.  The immune epitope database (IEDB) 3.0.

Authors:  Randi Vita; James A Overton; Jason A Greenbaum; Julia Ponomarenko; Jason D Clark; Jason R Cantrell; Daniel K Wheeler; Joseph L Gabbard; Deborah Hix; Alessandro Sette; Bjoern Peters
Journal:  Nucleic Acids Res       Date:  2014-10-09       Impact factor: 16.971
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  3 in total

1.  Safety, immunogenicity and protection of A(H3N2) live attenuated influenza vaccines containing wild-type nucleoprotein in a ferret model.

Authors:  Daniil A Korenkov; Karen L Laurie; Patrick C Reading; Louise A Carolan; Kok Fei Chan; Irina I Isakova-Sivak; Tatiana A Smolonogina; Kanta Subbarao; Ian G Barr; Julie Villanueva; Svetlana Shcherbik; Tatiana Bousse; Larisa G Rudenko
Journal:  Infect Genet Evol       Date:  2018-06-19       Impact factor: 3.342

2.  Sequential Immunization with Universal Live Attenuated Influenza Vaccine Candidates Protects Ferrets against a High-Dose Heterologous Virus Challenge.

Authors:  Irina Isakova-Sivak; Victoria Matyushenko; Tatiana Kotomina; Irina Kiseleva; Elena Krutikova; Svetlana Donina; Andrey Rekstin; Natalia Larionova; Daria Mezhenskaya; Konstantin Sivak; Arman Muzhikyan; Anastasia Katelnikova; Larisa Rudenko
Journal:  Vaccines (Basel)       Date:  2019-07-08

3.  A Live Attenuated Influenza Vaccine Elicits Enhanced Heterologous Protection When the Internal Genes of the Vaccine Are Matched to Those of the Challenge Virus.

Authors:  Andrew Smith; Laura Rodriguez; Maya El Ghouayel; Aitor Nogales; Jeffrey M Chamberlain; Katherine Sortino; Emma Reilly; Changyong Feng; David J Topham; Luis Martínez-Sobrido; Stephen Dewhurst
Journal:  J Virol       Date:  2020-01-31       Impact factor: 5.103
  3 in total

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