OBJECTIVES: Febuxostat, a nonpurine xanthine oxidase, is known to be effective and safe, even in patients with chronic kidney disease. However, there are insufficient data about the efficacy and safety of febuxostat in kidney transplant patients. MATERIALS AND METHODS: We reviewed medical records of all kidney transplant patients who were prescribed febuxostat between August 2012 and May 2015 at Asan Medical Center in Seoul, Korea. The efficacy and safety results of febuxostat in transplant patients were evaluated. To compare the efficacy of febuxostat, results of kidney transplant patients who were prescribed benzbromarone or allopurinol for more than 1 year during the same period were also reviewed. RESULTS: Thirty-one patients were included in this study. The initial serum uric acid level of 481.83 ± 143.36 μmol/L decreased to 302.18 ± 150.50 μmol/L after 1 month of febuxostat use. Only 1 patient had altered sense of taste after taking febuxostat, but this symptom quickly improved and he continued treatment. No other adverse events were reported. In addition, at 12 months, mean serum uric acid levels were 280.77 ± 78.52 μmol/L in the febuxostat, 332.52 ± 72.57 μmol/L in the benzbromarone, and 363.45 ± 60.08 μmol/L in the allopurinol group. However, we found no apparent effect on estimated glomerular filtration rate (P = .344). The mean doses of febuxostat, benzbromarone, and allopurinol were 52.31 ± 5.33 mg/day, 42.19 ± 1.69 mg/day, and 146.67 ± 16.52 mg/day. CONCLUSIONS: Febuxostat reduced serum uric acid levels effectively in kidney transplant patients without severe adverse events.
OBJECTIVES:Febuxostat, a nonpurine xanthine oxidase, is known to be effective and safe, even in patients with chronic kidney disease. However, there are insufficient data about the efficacy and safety of febuxostat in kidney transplantpatients. MATERIALS AND METHODS: We reviewed medical records of all kidney transplantpatients who were prescribed febuxostat between August 2012 and May 2015 at Asan Medical Center in Seoul, Korea. The efficacy and safety results of febuxostat in transplant patients were evaluated. To compare the efficacy of febuxostat, results of kidney transplantpatients who were prescribed benzbromarone or allopurinol for more than 1 year during the same period were also reviewed. RESULTS: Thirty-one patients were included in this study. The initial serum uric acid level of 481.83 ± 143.36 μmol/L decreased to 302.18 ± 150.50 μmol/L after 1 month of febuxostat use. Only 1 patient had altered sense of taste after taking febuxostat, but this symptom quickly improved and he continued treatment. No other adverse events were reported. In addition, at 12 months, mean serum uric acid levels were 280.77 ± 78.52 μmol/L in the febuxostat, 332.52 ± 72.57 μmol/L in the benzbromarone, and 363.45 ± 60.08 μmol/L in the allopurinol group. However, we found no apparent effect on estimated glomerular filtration rate (P = .344). The mean doses of febuxostat, benzbromarone, and allopurinol were 52.31 ± 5.33 mg/day, 42.19 ± 1.69 mg/day, and 146.67 ± 16.52 mg/day. CONCLUSIONS:Febuxostat reduced serum uric acid levels effectively in kidney transplantpatients without severe adverse events.
Authors: Arrigo F G Cicero; Federica Fogacci; Raffaele Ivan Cincione; Giuliano Tocci; Claudio Borghi Journal: Med Princ Pract Date: 2020-10-09 Impact factor: 1.927