| Literature DB >> 29250654 |
Alexandru Radu Mihailovici1, Ruxandra Camelia Deliu, Claudiu Mărgăritescu, Cristiana Eugenia Simionescu, IonuŢ Donoiu, Octavian Istrătoaie, Diana Rodica Tudoraşcu, Elena Anca Târtea, Dan IonuŢ Gheonea.
Abstract
The extracellular matrix (ECM) remodeling represents the pathological substrate of dilated cardiomyopathy (DCM). In this study, we statistically analyzed the immunoexpression of collagen I and III, matrix metalloproteinase-1 (MMP-1) and its tissue inhibitor-1 (TIMP-1) in the myocardial tissue in 18 cases of DCM compared to a control group. We observed a significant increase in the immunoexpression of collagen I and III in patients with DCM and a significant reduction in the immunoexpression of MMP-1 compared with the control group. Also, the collagen I and TIMP-1 expression indicated a positive linear correlation and respectively a negative linear relationship with collagen III and MMP-1. The analyzed markers in this study can be used to quantify the degree of collagen sclerosis from the ECM of DCM.Entities:
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Year: 2017 PMID： 29250654
Source DB: PubMed Journal: Rom J Morphol Embryol ISSN： 1220-0522 Impact factor: 1.033