Literature DB >> 2924919

Prothymosin alpha is a nuclear protein.

J D Watts1, P D Cary, C Crane-Robinson.   

Abstract

The cellular location of the so-called 'thymic hormone' prothymosin alpha has been studied by microinjection into the cytoplasm of Xenopus oocytes, followed by separate monitoring of nuclear and cytoplasmic concentrations. It is shown that prothymosin alpha migrates to the nucleus at a rate comparable to that of histone H1. Prothymosin alpha cannot therefore be a hormone in the usual sense of the word.

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Year:  1989        PMID： 2924919     DOI： 10.1016/0014-5793(89)80182-6

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  14 in total

1.  Novel function of prothymosin alpha as a potent inhibitor of human immunodeficiency virus type 1 gene expression in primary macrophages.

Authors:  Arevik Mosoian; Avelino Teixeira; Anthony A High; Robert E Christian; Donald F Hunt; Jeffrey Shabanowitz; Xinyan Liu; Mary Klotman
Journal:  J Virol       Date:  2006-09       Impact factor: 5.103

2.  Antiapoptotic function of RNA-binding protein HuR effected through prothymosin alpha.

Authors:  Ashish Lal; Tomoko Kawai; Xiaoling Yang; Krystyna Mazan-Mamczarz; Myriam Gorospe
Journal:  EMBO J       Date:  2005-04-28       Impact factor: 11.598

3.  Evidence for the extranuclear localization of thymosins in thymus.

Authors:  O E Tsitsiloni; P P Yialouris; H Echner; W Voelter; A A Haritos
Journal:  Experientia       Date:  1992-04-15

4.  Evidence for nuclear targeting of prothymosin and parathymosin synthesized in situ.

Authors:  M Clinton; L Graeve; H el-Dorry; E Rodriguez-Boulan; B L Horecker
Journal:  Proc Natl Acad Sci U S A       Date:  1991-08-01       Impact factor: 11.205

5.  Cellular levels of thymosin immunoreactive peptides are linked to proliferative events: evidence for a nuclear site of action.

Authors:  C N Conteas; M G Mutchnick; K C Palmer; F E Weller; G D Luk; P H Naylor; M R Erdos; A L Goldstein; C Panneerselvam; B L Horecker
Journal:  Proc Natl Acad Sci U S A       Date:  1990-05       Impact factor: 11.205

6.  Identification of estrogen-responsive genes in neuroblastoma SK-ER3 cells.

Authors:  M Garnier; D Di Lorenzo; A Albertini; A Maggi
Journal:  J Neurosci       Date:  1997-06-15       Impact factor: 6.167

7.  Overexpression of prothymosin alpha accelerates proliferation and retards differentiation in HL-60 cells.

Authors:  P Rodríguez; J E Viñuela; L Alvarez-Fernández; M Buceta; A Vidal; F Domínguez; J Gómez-Márquez
Journal:  Biochem J       Date:  1998-05-01       Impact factor: 3.857

8.  Evolution of prothymosin alpha and proliferating cell nuclear antigen (PCNA) immunoreactivity through the development of rat ovarian follicles.

Authors:  E Roson; R Gallego; T Garcia-Caballero; M Fraga; F Dominguez; A Beiras
Journal:  Histochem J       Date:  1993-07

9.  An E-box element localized in the first intron mediates regulation of the prothymosin alpha gene by c-myc.

Authors:  S Gaubatz; A Meichle; M Eilers
Journal:  Mol Cell Biol       Date:  1994-06       Impact factor: 4.272

10.  Do products of the myc proto-oncogene play a role in transcriptional regulation of the prothymosin alpha gene?

Authors:  P C Mol; R H Wang; D W Batey; L A Lee; C V Dang; S L Berger
Journal:  Mol Cell Biol       Date:  1995-12       Impact factor: 4.272
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