| Literature DB >> 2924917 |
K X Chen1, N Gresh, X Hui, B Pullman, K Zakrzewska.
Abstract
The nonintercalative groove binding of a simplified model of olivomycin, to sequences d(CGCGCGC)2, d(TATATAT)2, and d(CICICIC)2 is investigated. A significant preference is displayed for the minor groove of the d(CG) sequence. This is due predominantly to the formation of H-bonds between the hydroxyl groups on the aglycone of the drug and the 2-amino group of the central guanine of the oligonucleotide.Entities:
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Year: 1989 PMID： 2924917 DOI： 10.1016/0014-5793(89)80209-1
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124