Alisa R Kosheleff1, Jingwen Araki2, Jennifer Hsueh2, Andrew Le2, Kevin Quizon2, Sean B Ostlund3, Nigel T Maidment2, Niall P Murphy2. 1. Hatos Center for Neuropharmacology, Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California, 675 Charles E Young Dr. South, MRL #2762, Los Angeles, CA 90095, USA; Department of Psychology, University of California, Los Angeles, CA, USA. Electronic address: akosheleff@ucla.edu. 2. Hatos Center for Neuropharmacology, Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California, 675 Charles E Young Dr. South, MRL #2762, Los Angeles, CA 90095, USA. 3. Hatos Center for Neuropharmacology, Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California, 675 Charles E Young Dr. South, MRL #2762, Los Angeles, CA 90095, USA; Department of Anesthesiology and Perioperative Care, University of California, 3111 Gillespie Neuroscience Research Facility 837 Health Sciences Rd, Irvine, CA 92697, USA.
Abstract
AIMS: Like drug addiction, cues associated with palatable foods can trigger food-seeking, even when sated. However, whether susceptibility to the motivating influence of food-related cues is a predisposing factor in overeating or a consequence of poor diet is difficult to determine in humans. Using a rodent model, we explored whether a highly palatable 'junk food' diet impacts responses to reward-paired cues in a Pavlovian-to-instrumental transfer test, using sweetened condensed milk (SCM) as the reward. The hedonic impact of SCM consumption was also assessed by analyzing licking microstructure. METHODS: To probe the effects of pattern and duration of junk food exposure, we provided rats with either regular chow ad libitum (controls) or chow plus access to junk food for either 2 or 24 h per day for 1, 3, or 6 weeks. We also examined how individual susceptibility to weight gain related to these measures. RESULTS: Rats provided 24 h access to the junk food diet were insensitive to the motivational effects of a SCM-paired cue when tested sated even though their hedonic experience upon reward consumption was similar to controls. In contrast, rats provided restricted, 2 h access to junk food exhibited a cue generalization phenotype under sated conditions, lever-pressing with increased vigor in response to both a SCM-paired cue, and a cue not previously paired with reward. Hedonic response was also significantly higher in these animals relative to controls. CONCLUSIONS: These data demonstrate that the pattern of junk food exposure differentially alters the hedonic impact of palatable foods and susceptibility to the motivating influence of cues in the environment to promote food-seeking actions when sated, which may be consequential for understanding overeating and obesity.
AIMS: Like drug addiction, cues associated with palatable foods can trigger food-seeking, even when sated. However, whether susceptibility to the motivating influence of food-related cues is a predisposing factor in overeating or a consequence of poor diet is difficult to determine in humans. Using a rodent model, we explored whether a highly palatable 'junk food' diet impacts responses to reward-paired cues in a Pavlovian-to-instrumental transfer test, using sweetened condensed milk (SCM) as the reward. The hedonic impact of SCM consumption was also assessed by analyzing licking microstructure. METHODS: To probe the effects of pattern and duration of junk food exposure, we provided rats with either regular chow ad libitum (controls) or chow plus access to junk food for either 2 or 24 h per day for 1, 3, or 6 weeks. We also examined how individual susceptibility to weight gain related to these measures. RESULTS:Rats provided 24 h access to the junk food diet were insensitive to the motivational effects of a SCM-paired cue when tested sated even though their hedonic experience upon reward consumption was similar to controls. In contrast, rats provided restricted, 2 h access to junk food exhibited a cue generalization phenotype under sated conditions, lever-pressing with increased vigor in response to both a SCM-paired cue, and a cue not previously paired with reward. Hedonic response was also significantly higher in these animals relative to controls. CONCLUSIONS: These data demonstrate that the pattern of junk food exposure differentially alters the hedonic impact of palatable foods and susceptibility to the motivating influence of cues in the environment to promote food-seeking actions when sated, which may be consequential for understanding overeating and obesity.
Authors: S E la Fleur; L J M J Vanderschuren; M C Luijendijk; B M Kloeze; B Tiesjema; R A H Adan Journal: Int J Obes (Lond) Date: 2007-02-27 Impact factor: 5.095
Authors: Sean B Ostlund; Kimberly H LeBlanc; Alisa R Kosheleff; Kate M Wassum; Nigel T Maidment Journal: Neuropsychopharmacology Date: 2014-05-07 Impact factor: 7.853
Authors: Serena Becchi; Joshua Hood; Michael D Kendig; Aida Mohammadkhani; Megan L Shipman; Bernard W Balleine; Stephanie L Borgland; Laura H Corbit Journal: Psychopharmacology (Berl) Date: 2022-10-11 Impact factor: 4.415
Authors: Alisa R Kosheleff; Jingwen Araki; Linda Tsan; Grace Chen; Niall P Murphy; Nigel T Maidment; Sean B Ostlund Journal: Front Psychiatry Date: 2018-08-16 Impact factor: 4.157