| Literature DB >> 29248504 |
M Aydın1, Ö Ergönül2, A Azap3, H Bilgin4, G Aydın5, S A Çavuş6, Y Z Demiroğlu7, H E Alışkan8, O Memikoğlu3, Ş Menekşe9, Ş Kaya10, N A Demir11, I Karaoğlan12, S Başaran13, Ç Hatipoğlu14, Ş Erdinç14, E Yılmaz15, A Tümtürk16, Y Tezer16, H Demirkaya17, Ş E Çakar18, Ş Keske2, S Tekin2, C Yardımcı19, Ç Karakoç20, P Ergen21, Ö Azap17, L Mülazımoğlu4, O Ural11, F Can22, H Akalın15.
Abstract
This article describes the emergence of resistance and predictors of fatality for 1556 cases of healthcare-associated Gram-negative bloodstream infection in 2014 and 2015. The colistin resistance rate in Klebsiella pneumoniae was 16.1%, compared with 6% in 2013. In total, 660 (42.4%) cases were fatal. The highest fatality rate was among patients with Acinetobacter baumannii bacteraemia (58%), followed by Pseudomonas aeruginosa (45%), Klebsiella pneumoniae (41%), Enterobacter cloacae (32%) and Escherichia coli (28%). On multi-variate analysis, the minimum inhibitory concentrations for carbapenems [odds ratio (OR) 1.02, 95% confidence interval (CI) 1.01-1.04; P = 0.002] and colistin (OR 1.1, 95% CI 1.03-1.17; P = 0.001) were found to be significantly associated with fatality.Entities:
Keywords: Bloodstream; Colistin MIC; Gram-negative; Health care
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Year: 2017 PMID： 29248504 DOI： 10.1016/j.jhin.2017.11.014
Source DB: PubMed Journal: J Hosp Infect ISSN： 0195-6701 Impact factor: 3.926