Bünyamin Özgeriş1, Yusuf Akbaba2, Özlem Özdemir3, Hasan Türkez3, Süleyman Göksu4. 1. Department of Basic Sciences, Erzurum Technical University, Faculty of Science, Erzurum, Turkey. Electronic address: bunyamin.ozgeris@erzurum.edu.tr. 2. Department of Basic Sciences, Erzurum Technical University, Faculty of Science, Erzurum, Turkey. 3. Department of Molecular Biology and Genetics, Erzurum Technical University, Faculty of Science, Erzurum, Turkey. 4. Department of Chemistry, Atatürk University, Faculty of Science, Erzurum, Turkey.
Abstract
BACKGROUND AND AIMS: In the present study, a series of ureas and sulfamides derived from 1-aminotetralins were synthesized. For this purpose, urea and sulfamide analogues were synthesized from the reactions of substituted 1-aminotetralins with N,N-dimethylcarbamoyl chloride and N,N-dimethylsulfamoyl chloride. The anticancer activity of newly synthesized compounds was tested against human U-87MG glioblastoma and PC-3 prostate cancer cell lines. Cytotoxicity was examined using MTT and LDH release assays. RESULTS: The obtained data revealed that tested compounds showed a variable degree of cytotoxic activity against the tested cell lines. 3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)-1,1-dimethylurea (9) and 3-(6-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)-1,1-dimethylurea (10) proved to be the most active cytotoxic members in this study. CONCLUSIONS: These two compounds could be considered as possible anticancer agents.
BACKGROUND AND AIMS: In the present study, a series of ureas and sulfamides derived from 1-aminotetralins were synthesized. For this purpose, urea and sulfamide analogues were synthesized from the reactions of substituted 1-aminotetralins with N,N-dimethylcarbamoyl chloride and N,N-dimethylsulfamoyl chloride. The anticancer activity of newly synthesized compounds was tested against humanU-87MG glioblastoma and PC-3prostate cancer cell lines. Cytotoxicity was examined using MTT and LDH release assays. RESULTS: The obtained data revealed that tested compounds showed a variable degree of cytotoxic activity against the tested cell lines. 3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)-1,1-dimethylurea (9) and 3-(6-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)-1,1-dimethylurea (10) proved to be the most active cytotoxic members in this study. CONCLUSIONS: These two compounds could be considered as possible anticancer agents.