Ruta Zukauskaite1, Christian R Hansen2, Cai Grau3, Eva Samsøe4, Jørgen Johansen5, Jørgen B B Petersen3, Elo Andersen6, Carsten Brink2, Jens Overgaard7, Jesper G Eriksen8. 1. Department of Oncology, Odense University Hospital, Denmark; Institute of Clinical Research, University of Southern Denmark, Denmark. Electronic address: ruta.zukauskaite@rsyd.dk. 2. Institute of Clinical Research, University of Southern Denmark, Denmark; Laboratory of Radiation Physics, Odense University Hospital, Denmark. 3. Department of Oncology, Aarhus University Hospital, Denmark. 4. Radiotherapy Research Unit, Herlev and Gentofte Hospital, University of Copenhagen, Denmark. 5. Department of Oncology, Odense University Hospital, Denmark. 6. Department of Oncology, Herlev and Gentofte Hospital, Denmark. 7. Department of Experimental Clinical Oncology, Aarhus University Hospital, Denmark. 8. Department of Oncology, Odense University Hospital, Denmark; Institute of Clinical Research, University of Southern Denmark, Denmark.
Abstract
INTRODUCTION: The aim was to analyze position of CT-verified local recurrences (LR) and local control (LC) among three centers that used different GTV to CTV1 margins. MATERIALS AND METHODS: In total, 1576 patients completing radical primary IMRT for larynx, pharynx, oral cavity HNSCC in three centers in Denmark between 2006 and 2012 were included. CT-verified LRs were analyzed as possible points of recurrence origin and compared between groups of small (0-2.5 mm), larger (>2.5 mm), and anatomical GTV-CTV1 margins. The recurrence point's position relative to the GTV and 95% prescription dose was evaluated. Overall local control rate was evaluated using Cox uni- and multi-variate analysis. RESULTS: After a median follow-up of 41 months, 272 patients had local failure. Median GTV-CTV1 margin in Center1, 2 and 3 was 0.0, 3.7 and 9.7 mm, respectively. 51% of local recurrences were inside the GTV. No difference in distribution of LRs in relation to GTV surface (p = 0.4) or the dose to LRs (p = 0.2) was detected between the groups. A difference in LC was found univariate between the centers (p = 0.03), but not in multivariate analysis (p = 0.4). CONCLUSIONS: No relation was found between the recurrences' distributions as function of the margins used at three centers. In multivariate analysis, local control was not influenced by the centers.
INTRODUCTION: The aim was to analyze position of CT-verified local recurrences (LR) and local control (LC) among three centers that used different GTV to CTV1 margins. MATERIALS AND METHODS: In total, 1576 patients completing radical primary IMRT for larynx, pharynx, oral cavity HNSCC in three centers in Denmark between 2006 and 2012 were included. CT-verified LRs were analyzed as possible points of recurrence origin and compared between groups of small (0-2.5 mm), larger (>2.5 mm), and anatomical GTV-CTV1 margins. The recurrence point's position relative to the GTV and 95% prescription dose was evaluated. Overall local control rate was evaluated using Cox uni- and multi-variate analysis. RESULTS: After a median follow-up of 41 months, 272 patients had local failure. Median GTV-CTV1 margin in Center1, 2 and 3 was 0.0, 3.7 and 9.7 mm, respectively. 51% of local recurrences were inside the GTV. No difference in distribution of LRs in relation to GTV surface (p = 0.4) or the dose to LRs (p = 0.2) was detected between the groups. A difference in LC was found univariate between the centers (p = 0.03), but not in multivariate analysis (p = 0.4). CONCLUSIONS: No relation was found between the recurrences' distributions as function of the margins used at three centers. In multivariate analysis, local control was not influenced by the centers.
Authors: Adam R Burr; Paul M Harari; Huaising C Ko; Justine Y Bruce; Randall J Kimple; Matthew E Witek Journal: Oral Oncol Date: 2019-03-22 Impact factor: 5.337
Authors: Hans Ligtenberg; Stefan M Willems; Lilian N Ruiter; Elise Anne Jager; Chris H J Terhaard; Cornelis P J Raaijmakers; Marielle E P Philippens Journal: Clin Transl Radiat Oncol Date: 2018-07-11
Authors: Ruta Zukauskaite; Christopher N Rumley; Christian R Hansen; Michael G Jameson; Yuvnik Trada; Jørgen Johansen; Niels Gyldenkerne; Jesper G Eriksen; Farhannah Aly; Rasmus L Christensen; Mark Lee; Carsten Brink; Lois Holloway Journal: Clin Transl Radiat Oncol Date: 2022-08-06