Wilson Bautista-Molano1,2, Robert Landewé3,4, Rubén Burgos-Vargas3,4, José Maldonado-Cocco3,4, Anna Moltó3,4, Filip van den Bosch3,4, Rafael Valle-Oñate3,4, Maxime Dougados3,4, Désirée van der Heijde3,4. 1. From the Rheumatology Department, Leiden University Medical Center, Leiden, the Netherlands; School of Medicine, Universidad Militar Nueva Granada and Rheumatology Department, Hospital Militar, Bogotá, Colombia; Amsterdam Rheumatology and Clinical Immunology Center, Amsterdam; Zuyderland Medical Center Heerlen, Heerlen, the Netherlands; Servicio de Reumatología, Hospital General de México and Universidad Nacional Autónoma de México, Mexico City, Mexico; School of Medicine, Buenos Aires University and Argentine Rheumatologic Foundation Dr. Osvaldo Carcia Morteo, Buenos Aires, Argentina; Rheumatology B Department, Paris Descartes University, Cochin Hospital, AP-HP; INSERM (U1153): Clinical epidemiology and biostatistics, PRES Sorbonne Paris-Cité, Paris, France; Department of Rheumatology, Ghent University Hospital, Ghent, Belgium. wilson.bautista@gmail.com. 2. W. Bautista-Molano, MD, Rheumatology Department, Leiden University Medical Center, and School of Medicine, Universidad Militar Nueva Granada and Rheumatology Department, Hospital Militar; R. Landewé, MD, PhD, Amsterdam Rheumatology and Clinical Immunology Center, and Zuyderland Medical Center Heerlen; R. Burgos-Vargas, MD, Servicio de Reumatología, Hospital General de México and Universidad Nacional Autónoma de México; J. Maldonado-Cocco, MD, School of Medicine, Buenos Aires University and Argentine Rheumatologic Foundation Dr. Osvaldo Carcia Morteo; A. Moltó, MD, PhD, Rheumatology B Department, Paris Descartes University, Cochin Hospital, AP-HP, and INSERM (U1153): Clinical epidemiology and biostatistics, PRES Sorbonne Paris-Cité; F. van den Bosch, MD, PhD, Department of Rheumatology, Ghent University Hospital; R. Valle-Oñate, MD, School of Medicine, Universidad Militar Nueva Granada and Rheumatology Department, Hospital Militar; M. Dougados, MD, Rheumatology B Department, Paris Descartes University, Cochin Hospital, AP-HP, and INSERM (U1153): Clinical epidemiology and biostatistics, PRES Sorbonne Paris-Cité; D. van der Heijde, MD, PhD, Rheumatology Department, Leiden University Medical Center. wilson.bautista@gmail.com. 3. From the Rheumatology Department, Leiden University Medical Center, Leiden, the Netherlands; School of Medicine, Universidad Militar Nueva Granada and Rheumatology Department, Hospital Militar, Bogotá, Colombia; Amsterdam Rheumatology and Clinical Immunology Center, Amsterdam; Zuyderland Medical Center Heerlen, Heerlen, the Netherlands; Servicio de Reumatología, Hospital General de México and Universidad Nacional Autónoma de México, Mexico City, Mexico; School of Medicine, Buenos Aires University and Argentine Rheumatologic Foundation Dr. Osvaldo Carcia Morteo, Buenos Aires, Argentina; Rheumatology B Department, Paris Descartes University, Cochin Hospital, AP-HP; INSERM (U1153): Clinical epidemiology and biostatistics, PRES Sorbonne Paris-Cité, Paris, France; Department of Rheumatology, Ghent University Hospital, Ghent, Belgium. 4. W. Bautista-Molano, MD, Rheumatology Department, Leiden University Medical Center, and School of Medicine, Universidad Militar Nueva Granada and Rheumatology Department, Hospital Militar; R. Landewé, MD, PhD, Amsterdam Rheumatology and Clinical Immunology Center, and Zuyderland Medical Center Heerlen; R. Burgos-Vargas, MD, Servicio de Reumatología, Hospital General de México and Universidad Nacional Autónoma de México; J. Maldonado-Cocco, MD, School of Medicine, Buenos Aires University and Argentine Rheumatologic Foundation Dr. Osvaldo Carcia Morteo; A. Moltó, MD, PhD, Rheumatology B Department, Paris Descartes University, Cochin Hospital, AP-HP, and INSERM (U1153): Clinical epidemiology and biostatistics, PRES Sorbonne Paris-Cité; F. van den Bosch, MD, PhD, Department of Rheumatology, Ghent University Hospital; R. Valle-Oñate, MD, School of Medicine, Universidad Militar Nueva Granada and Rheumatology Department, Hospital Militar; M. Dougados, MD, Rheumatology B Department, Paris Descartes University, Cochin Hospital, AP-HP, and INSERM (U1153): Clinical epidemiology and biostatistics, PRES Sorbonne Paris-Cité; D. van der Heijde, MD, PhD, Rheumatology Department, Leiden University Medical Center.
Abstract
OBJECTIVE: Increased risk of comorbidities has been reported in spondyloarthritis (SpA). The objective of this study was to determine the prevalence and risk of developing comorbidities in patients with SpA in 3 Latin American (LA) countries, and to compare that prevalence with the general population. METHODS: Data were analyzed from 390 patients with SpA enrolled in the Assessment of SpondyloArthritis international Society of Comorbidities in SpA study from Argentina, Colombia, and Mexico. Age- and sex-standardized prevalence (95% CI) was estimated for arterial hypertension (AHT), tuberculosis (TB), and malignancies. Age- and sex-specific data from the general population were obtained from the Cardiovascular Risk Factor Multiple Evaluation in Latin America (CARMELA) study for AHT, the Global TB report, and the GLOBOCAN project for malignancies. Data analyzed for AHT were confined to Colombia and Mexico. The prevalence in patients with SpA was compared with the prevalence in the general population per age- and sex-specific stratum, resulting in standardized risk ratios (SRR). RESULTS: In total, 64% of the patients with SpA were male, with a mean age of 45 years (SD 14.7). The most common comorbidities in the 3 LA countries were AHT (25.3%, 95% CI 21.2-30.0), hypercholesterolemia (21.5%, 95% CI 17.6-26.0), and osteoporosis (9.4%, 95% CI 6.8-12.9). AHT prevalence in Colombia and Mexico was 21.4% (95% CI 15.4-28.9) and was higher than the general population (12.5%, 95% CI 11.4-13.7), resulting in an SRR of 1.5. TB prevalence in the 3 LA countries was 3.3% (95% CI 1.8-5.7), which was significantly higher than in the general population (0.32%), leading to an SRR of 10.3. The prevalence of malignancies was not increased. CONCLUSION: Patients with SpA in LA are at increased risk of AHT and TB in comparison to the general population. While this sample of patients may not be entirely representative of the patient population in each country, a systematic evaluation of these comorbidities in all patients with SpA still may help to monitor these conditions better.
OBJECTIVE: Increased risk of comorbidities has been reported in spondyloarthritis (SpA). The objective of this study was to determine the prevalence and risk of developing comorbidities in patients with SpA in 3 Latin American (LA) countries, and to compare that prevalence with the general population. METHODS: Data were analyzed from 390 patients with SpA enrolled in the Assessment of SpondyloArthritis international Society of Comorbidities in SpA study from Argentina, Colombia, and Mexico. Age- and sex-standardized prevalence (95% CI) was estimated for arterial hypertension (AHT), tuberculosis (TB), and malignancies. Age- and sex-specific data from the general population were obtained from the Cardiovascular Risk Factor Multiple Evaluation in Latin America (CARMELA) study for AHT, the Global TB report, and the GLOBOCAN project for malignancies. Data analyzed for AHT were confined to Colombia and Mexico. The prevalence in patients with SpA was compared with the prevalence in the general population per age- and sex-specific stratum, resulting in standardized risk ratios (SRR). RESULTS: In total, 64% of the patients with SpA were male, with a mean age of 45 years (SD 14.7). The most common comorbidities in the 3 LA countries were AHT (25.3%, 95% CI 21.2-30.0), hypercholesterolemia (21.5%, 95% CI 17.6-26.0), and osteoporosis (9.4%, 95% CI 6.8-12.9). AHT prevalence in Colombia and Mexico was 21.4% (95% CI 15.4-28.9) and was higher than the general population (12.5%, 95% CI 11.4-13.7), resulting in an SRR of 1.5. TB prevalence in the 3 LA countries was 3.3% (95% CI 1.8-5.7), which was significantly higher than in the general population (0.32%), leading to an SRR of 10.3. The prevalence of malignancies was not increased. CONCLUSION:Patients with SpA in LA are at increased risk of AHT and TB in comparison to the general population. While this sample of patients may not be entirely representative of the patient population in each country, a systematic evaluation of these comorbidities in all patients with SpA still may help to monitor these conditions better.
Authors: Gustavo Citera; Wilson Bautista-Molano; Ingris Peláez-Ballestas; Valderilio F Azevedo; Risto A Perich; José A Méndez-Rodríguez; Mariel S Cutri; Cecilia E Borlenghi Journal: Adv Rheumatol Date: 2021-01-08
Authors: Clementina López-Medina; Anna Molto; Joachim Sieper; Tuncay Duruöz; Uta Kiltz; Bassel Elzorkany; Najia Hajjaj-Hassouni; Ruben Burgos-Vargas; José Maldonado-Cocco; Nelly Ziade; Meghna Gavali; Victoria Navarro-Compan; Shue-Fen Luo; Sara Monti; Kim Tae-Jong; Mitsumasa Kishimoto; F M Pimentel-Santos; Jieruo Gu; Ruxandra Schiotis; Floris A van Gaalen; Pál Geher; Marina Magrey; Sebastián E Ibáñez Vodnizza; Wilson Bautista-Molano; Walter Maksymowych; Pedro M Machado; Robert Landewé; Desirée van der Heijde; Maxime Dougados Journal: RMD Open Date: 2021-01