Nina Droz1, Vincent Enouf2, Philippe Bidet3, Damir Mohamed4, Sylvie Behillil2, Anne-Laure Simon5, Manon Bachy6, Marion Caseris7, Stéphane Bonacorsi3, Romain Basmaci8. 1. Pediatric-Emergency Department, Louis-Mourier Hospital, AP-HP, Colombes, France. 2. Coordinating Center of the National Reference Center for Influenza Viruses, Institut Pasteur, UMR 3569 CNRS, Paris Diderot-Paris 7 University, Sorbonne Paris Cité. 3. Department of Microbiology, Robert Debré Hospital, AP-HP, Associated-National Reference Center for Escherichia Coli, Paris, France; IAME, UMR 1137, INSERM, Paris Diderot University, Sorbonne Paris Cité. 4. Unit of Clinical Epidemiology, Robert Debré Hospital, AP-HP, Paris, France; Inserm, CIC-EC 1426, Paris, France. 5. Department of Pediatric Orthopedic Surgery, Robert Debré Hospital, AP-HP, Paris, France. 6. Department of Pediatric Orthopedic Surgery, Armand Trousseau Hospital, APHP, Pierre et Marie Curie Paris 6 University, Paris, France. 7. Department of Pediatric Infectious Diseases, Robert Debré Hospital, AP-HP, Paris, France. 8. Pediatric-Emergency Department, Louis-Mourier Hospital, AP-HP, Colombes, France; IAME, UMR 1137, INSERM, Paris Diderot University, Sorbonne Paris Cité. Electronic address: romain.basmaci@aphp.fr.
Abstract
OBJECTIVE: To determine whether the seasonal distribution of Kingella kingae osteoarticular infections is similar to that of common respiratory viruses. STUDY DESIGN: Between October 2009 and September 2016, we extracted the results of K kingae-specific real-time polymerase chain reaction analyses performed for bone or joint specimens in patients from 2 pediatric tertiary care centers in Paris. We used data of respiratory virus detection from the Réseau National des Laboratoires network with coordination with the National Influenza Center of France. The Spearman rank correlation was used to assess a correlation between weekly distributions, with P < .05 denoting a significant correlation. RESULTS: During the 7-year study period, 322 children were diagnosed with K kingae osteoarticular infection, and 317 testing episodes were K kingae-negative. We observed high activity for both K kingae osteoarticular infection and human rhinovirus (HRV) during the fall (98 [30.4%] and 2401 [39.1%] cases, respectively) and low activity during summer (59 [18.3%] and 681 [11.1%] cases, respectively). Weekly distributions of K kingae osteoarticular infection and rhinovirus activity were significantly correlated (r = 0.30; P = .03). In contrast, no significant correlation was found between the weekly distribution of K kingae osteoarticular infection and other respiratory viruses (r = -0.17, P = .34 compared with respiratory syncytial virus; r = -0.13, P = .34 compared with influenza virus; and r = -0.22, P = .11 compared with metapneumovirus). CONCLUSION: A significant temporal association was observed between HRV circulation and K kingae osteoarticular infection, strengthening the hypothesis of a role of viral infections in the pathophysiology of K kingae invasive infection.
OBJECTIVE: To determine whether the seasonal distribution of Kingella kingae osteoarticular infections is similar to that of common respiratory viruses. STUDY DESIGN: Between October 2009 and September 2016, we extracted the results of K kingae-specific real-time polymerase chain reaction analyses performed for bone or joint specimens in patients from 2 pediatric tertiary care centers in Paris. We used data of respiratory virus detection from the Réseau National des Laboratoires network with coordination with the National Influenza Center of France. The Spearman rank correlation was used to assess a correlation between weekly distributions, with P < .05 denoting a significant correlation. RESULTS: During the 7-year study period, 322 children were diagnosed with K kingae osteoarticular infection, and 317 testing episodes were K kingae-negative. We observed high activity for both K kingae osteoarticular infection and human rhinovirus (HRV) during the fall (98 [30.4%] and 2401 [39.1%] cases, respectively) and low activity during summer (59 [18.3%] and 681 [11.1%] cases, respectively). Weekly distributions of K kingae osteoarticular infection and rhinovirus activity were significantly correlated (r = 0.30; P = .03). In contrast, no significant correlation was found between the weekly distribution of K kingae osteoarticular infection and other respiratory viruses (r = -0.17, P = .34 compared with respiratory syncytial virus; r = -0.13, P = .34 compared with influenza virus; and r = -0.22, P = .11 compared with metapneumovirus). CONCLUSION: A significant temporal association was observed between HRV circulation and K kingae osteoarticular infection, strengthening the hypothesis of a role of viral infections in the pathophysiology of K kingae invasive infection.