Literature DB >> 29246338

Cardiorespiratory Capacity and Strength Remain Attenuated in Children with Severe Burn Injuries at Over 3 Years Postburn.

Janos Cambiaso-Daniel1, Eric Rivas2, Joshua S Carson3, Gabriel Hundeshagen4, Omar Nunez Lopez5, Shauna Q Glover5, David N Herndon5, Oscar E Suman6.   

Abstract

OBJECTIVES: To compare physical capacity and body composition between children with burn injuries at approximately 4 years postburn and healthy, fit children. STUDY
DESIGN: In this retrospective, case-control study, we analyzed the strength, aerobic capacity, and body composition of children with severe burn injuries (n = 40) at discharge, after completion of a 6- to 12-week rehabilitative exercise training program, and at 3-4 years postburn. Values were expressed as a relative percentage of those in age- and sex-matched children for comparison (n = 40 for discharge and postexercise; n = 40 for 3.5 years postburn).
RESULTS: At discharge, lean body mass was 89% of that in children without burn injuries, and exercise rehabilitation restored this to 94% (P < .01). At 3.5 years postburn, lean body mass (94%), bone mineral content (89%), and bone mineral density (93%; each P ≤ .02) remained reduced, whereas total body fat was increased (148%, P = .01). Cardiorespiratory fitness remained lower in children with burn injuries both after exercise training (75%; P < .0001) and 3.5 years later (87%; P < .001). Peak torque (60%; P < .0001) and average power output (58%; P < .0001) were lower after discharge. Although exercise training improved these, they failed to reach levels achieved in healthy children without burns (83-84%; P < .0001) but were maintained at 85% and 82%, respectively, 3.5 years later (P < .0001).
CONCLUSIONS: Although the benefits of rehabilitative exercise training on strength and cardiorespiratory capacity are maintained at almost 4 years postburn, they are not restored fully to the levels of healthy children. Although the underlying mechanism of this phenomenon remains elusive, these findings suggest that future development of continuous exercise rehabilitation interventions after discharge may further narrow the gap in relation to healthy adolescents. Published by Elsevier Inc.

Entities:  

Keywords:  body composition; exercise program; muscle strength; peak aerobic capacity; rehabilitation; standard of care

Mesh:

Year:  2018        PMID: 29246338      PMCID: PMC5739078          DOI: 10.1016/j.jpeds.2017.09.015

Source DB:  PubMed          Journal:  J Pediatr        ISSN: 0022-3476            Impact factor:   4.406


  37 in total

Review 1.  The role of exercise in the rehabilitation of patients with severe burns.

Authors:  Craig Porter; Justin P Hardee; David N Herndon; Oscar E Suman
Journal:  Exerc Sport Sci Rev       Date:  2015-01       Impact factor: 6.230

Review 2.  Post burn muscle wasting and the effects of treatments.

Authors:  Clifford Pereira; Kevin Murphy; Marc Jeschke; David N Herndon
Journal:  Int J Biochem Cell Biol       Date:  2005-10       Impact factor: 5.085

3.  Growth delay in postburn pediatric patients.

Authors:  R L Rutan; D N Herndon
Journal:  Arch Surg       Date:  1990-03

4.  Effects of exercise training on resting energy expenditure and lean mass during pediatric burn rehabilitation.

Authors:  Ahmed M Al-Mousawi; Felicia N Williams; Ronald P Mlcak; Marc G Jeschke; David N Herndon; Oscar E Suman
Journal:  J Burn Care Res       Date:  2010 May-Jun       Impact factor: 1.845

5.  Beneficial effects of extended growth hormone treatment after hospital discharge in pediatric burn patients.

Authors:  Rene Przkora; David N Herndon; Oscar E Suman; Marc G Jeschke; Walter J Meyer; David L Chinkes; Ronald P Mlcak; Ted Huang; Robert E Barrow
Journal:  Ann Surg       Date:  2006-06       Impact factor: 12.969

6.  Muscle protein catabolism after severe burn: effects of IGF-1/IGFBP-3 treatment.

Authors:  D N Herndon; P I Ramzy; M A DebRoy; M Zheng; A A Ferrando; D L Chinkes; J P Barret; R R Wolfe; S E Wolf
Journal:  Ann Surg       Date:  1999-05       Impact factor: 12.969

7.  The effects of oxandrolone and exercise on muscle mass and function in children with severe burns.

Authors:  Rene Przkora; David N Herndon; Oscar E Suman
Journal:  Pediatrics       Date:  2006-11-27       Impact factor: 7.124

8.  Competence and physical impairment of pediatric survivors of burns of more than 80% total body surface area.

Authors:  P Moore; M Moore; P Blakeney; W Meyer; L Murphy; D Herndon
Journal:  J Burn Care Rehabil       Date:  1996 Nov-Dec

9.  Long-term effects of physical exercise during rehabilitation in patients with severe burns.

Authors:  Paul Wurzer; Charles D Voigt; Robert P Clayton; Clark R Andersen; Ronald P Mlcak; Lars-P Kamolz; David N Herndon; Oscar E Suman
Journal:  Surgery       Date:  2016-06-03       Impact factor: 3.982

10.  A comparison of conservative versus early excision. Therapies in severely burned patients.

Authors:  D N Herndon; R E Barrow; R L Rutan; T C Rutan; M H Desai; S Abston
Journal:  Ann Surg       Date:  1989-05       Impact factor: 12.969

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  5 in total

1.  Relationship between lean body mass and isokinetic peak torque of knee extensors and flexors in severely burned children.

Authors:  Christian Tapking; Andrew M Armenta; Daniel Popp; David N Herndon; Ludwik K Branski; Jong O Lee; Oscar E Suman
Journal:  Burns       Date:  2018-09-29       Impact factor: 2.744

2.  Estimated versus achieved maximal oxygen consumption in severely burned children maximal oxygen consumption in burned children.

Authors:  Christian Tapking; Daniel Popp; David N Herndon; Ludwik K Branski; Ronald P Mlcak; Oscar E Suman
Journal:  Burns       Date:  2018-07-10       Impact factor: 2.744

Review 3.  Rehabilitative Exercise Training for Burn Injury.

Authors:  Alen Palackic; Oscar E Suman; Craig Porter; Andrew J Murton; Craig G Crandall; Eric Rivas
Journal:  Sports Med       Date:  2021-08-02       Impact factor: 11.136

4.  Impact of critical illness and withholding of early parenteral nutrition in the pediatric intensive care unit on long-term physical performance of children: a 4-year follow-up of the PEPaNIC randomized controlled trial.

Authors:  Ilse Vanhorebeek; An Jacobs; Liese Mebis; Karolijn Dulfer; Renate Eveleens; Hanna Van Cleemput; Pieter J Wouters; Ines Verlinden; Koen Joosten; Sascha Verbruggen; Greet Van den Berghe
Journal:  Crit Care       Date:  2022-05-12       Impact factor: 19.334

5.  Cardiovascular Effect of Varying Interval Training Frequency in Rehabilitation of Severely Burned Children.

Authors:  Christian Tapking; Daniel Popp; David N Herndon; Andrew M Armenta; Ludwik K Branski; Andrew J Murton; Oscar E Suman
Journal:  J Burn Care Res       Date:  2019-01-01       Impact factor: 1.845

  5 in total

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