Literature DB >> 2924586

Lack of toxicity of a topical recombinant interferon alpha.

M Smith1, M D Trousdale, N A Rao, J B Robin.   

Abstract

We evaluated the potential ocular surface toxicity of a recombinant interferon-alpha (IFN alpha) preparation on rabbit eyes. Topical application of this interferon (1 x 10(6) U/day in each eye) for 6 weeks produced no discernible conjunctival or corneal abnormalities on clinical, histopathologic, or ultrastructural evaluations. We believe that this recombinant IFN alpha preparation is not toxic to the ocular surface of rabbits.

Entities:  

Mesh：

Substances：

Year:  1989        PMID： 2924586

Source DB:  PubMed          Journal:  Cornea        ISSN： 0277-3740            Impact factor:   2.651


  6 in total

1.  Ocular surface toxicity associated with topical interferon alpha-2b.

Authors:  Anthony J Aldave; Anne Nguyen
Journal:  Br J Ophthalmol       Date:  2007-08       Impact factor: 4.638

2.  [Unclear monocular chronic reddening of the conjunctiva with ptosis].

Authors:  K Porubská; J M Rohrbach
Journal:  Ophthalmologe       Date:  2008-09       Impact factor: 1.059

3.  [Adjuvant topical interferon-alpha-2b treatment in epithelial tumors of the ocular surface].

Authors:  T A Fuchsluger; C Hintschich; K-P Steuhl; D Meller
Journal:  Ophthalmologe       Date:  2006-02       Impact factor: 1.059

4.  Interferon-alpha 2b inhibits proliferation of human Tenon's capsule fibroblasts.

Authors:  M Gillies; T Su; M Sarossy; F Hollows
Journal:  Graefes Arch Clin Exp Ophthalmol       Date:  1993-02       Impact factor: 3.117

5.  Ocular surface tumors.

Authors:  Ihab Saad Othman
Journal:  Oman J Ophthalmol       Date:  2009-01

6.  Resolution of primary acquired melanosis with atypia after treatment with topical mitomycin C and interferon alfa-2b.

Authors:  Fariba Ghassemi; Hadi Ghadimi; Mojgan Nikdel
Journal:  J Ophthalmic Vis Res       Date:  2015 Jan-Mar
  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.