| Literature DB >> 29245120 |
Yan-Ping Liu1, Jin-Ying Tang2, Yan Hua3, Liang Lai1, Xiu-Lan Luo1, Zhi-Jie Zhang1, Wen-Qing Yin3, Guang-Ying Chen2, Yan-Hui Fu4.
Abstract
Six new polyoxygenated seco-cyclohexenes, artahongkongenes A-F (1-6), together with six known analogues (7-12) were isolated from the stems and leaves of Artabotrys hongkongensis. Their structures were elucidated by extensive spectroscopic methods. All new compounds were evaluated for their cytotoxicities against five human cancer cell lines: HL-60, SMMC-7721, A-549, MCF-7 and SW480 in vitro. New seco-cyclohexenes 1-6 showed significant inhibitory effects against various human cancer cell lines with IC50 values ranging from 0.26 to 16.58 μM.Entities:
Keywords: Artabotrys hongkongensis; Artahongkongenes A–F; Cytotoxicities; Polyoxygenated seco-cyclohexenes
Mesh：
Substances：
Year: 2017 PMID： 29245120 DOI： 10.1016/j.bioorg.2017.12.011
Source DB: PubMed Journal: Bioorg Chem ISSN： 0045-2068 Impact factor: 5.275