| Literature DB >> 29243644 |
Gustavo Guadagnucci Fontanari1, José Paschoal Batistuti2, Robison José da Cruz3, Paulo Hilário Nascimento Saldiva4, José Alfredo Gomes Arêas5.
Abstract
This study describes the hypocholesterolaemic effect of whole lupin and its protein in hamsters. The diets were: casein (control group HC), lupin protein isolate (group HPI) and whole lupin seed (group HWS). Diets from HPI and HWS promoted a significant reduction of total cholesterol and non-HDL cholesterol in the hamsters' plasma as compared with HC. The true digestibility of HPI and HC groups were similar and differed significantly from the HWS one, which in turn showed a significant difference in total sterol excretion as compared to the former groups. Histological analysis of the liver revealed that animals fed on HPI and HWS diets presented a low level of steatosis (level 1) as compared to the ones fed on HC diet (level 4). Our findings demonstrate that protein isolate from Lupinus albus from Brazil has a metabolic effect on endogenous cholesterol metabolism and a protector effect on development of hepatic steatosis.Entities:
Keywords: Cholesterol; Hamsters; Hypocholesterolemia; Lupinus albus; Protein isolate; Steatosis
Year: 2011 PMID： 29243644 DOI： 10.1016/j.foodchem.2011.11.145
Source DB: PubMed Journal: Food Chem ISSN： 0308-8146 Impact factor: 7.514