Sayantan Nath 1 , Sambuddha Das 1 , Aditi Bhowmik 1 , Sankar Kumar Ghosh 1,2 , Yashmin Choudhury 1 Show Affiliations »
Abstract
BACKGROUND: Studies pertaining to association of GSTM1 and GSTT1 null genotypes with risk of T2DM and its complications were often inconclusive, thus spurring the present study. METHODS: Meta-analysis of 25 studies for evaluating the role of GSTM1/GSTT1 null polymorphisms in determining the risk for T2DM and 17 studies for evaluating the role of GSTM1/GSTT1 null polymorphisms in development of T2DM related complications were conducted. RESULTS: Our study revealed an association between GSTM1 and GSTT1 null polymorphism with T2DM (GSTM1; OR=1.37;95% CI =1.10-1.70 and GSTT1; OR=1.29;95% CI =1.04-1.61) with an amplified risk of 2.02 fold for combined GSTM1-GSTT1 null genotypes. Furthermore, the GSTT1 null (OR=1.56;95%CI=1.38-1.77) and combined GSTM1-GSTT1 null genotypes (OR=1.91;95%CI=1.25- 2.94) increased the risk for development of T2DM related complications, but not the GSTM1 null genotype. Stratified analyses based on ethnicity revealed GSTM1 and GSTT1 null genotypes increase the risk for T2DM in both Caucasians and Asians, with Asians showing much higher risk of T2DM complications than Caucasians for the same. DISCUSSION: GSTM1, GSTT1 and combined GSTM1-GSTT1 null polymorphism may be associated with increased risk for T2DM; while GSTT1 and combined GSTM1-GSTT1 null polymorphism may increase the risk of subsequent development of T2DM complications with Asian population carrying an amplified risk for the polymorphism. CONCLUSION: Thus GSTM1 and GSTT1 null genotypes increases the risk for Type 2 diabetes mellitus alone, in combination or with regards to ethnicity. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.
BACKGROUND: Studies pertaining to association of GSTM1 and GSTT1 null genotypes with risk of T2DM and its complications were often inconclusive, thus spurring the present study. METHODS: Meta-analysis of 25 studies for evaluating the role of GSTM1 /GSTT1 null polymorphisms in determining the risk for T2DM and 17 studies for evaluating the role of GSTM1 /GSTT1 null polymorphisms in development of T2DM related complications were conducted. RESULTS: Our study revealed an association between GSTM1 and GSTT1 null polymorphism with T2DM (GSTM1 ; OR=1.37;95% CI =1.10-1.70 and GSTT1 ; OR=1.29;95% CI =1.04-1.61) with an amplified risk of 2.02 fold for combined GSTM1 -GSTT1 null genotypes. Furthermore, the GSTT1 null (OR=1.56;95%CI=1.38-1.77) and combined GSTM1 -GSTT1 null genotypes (OR=1.91;95%CI=1.25- 2.94) increased the risk for development of T2DM related complications, but not the GSTM1 null genotype. Stratified analyses based on ethnicity revealed GSTM1 and GSTT1 null genotypes increase the risk for T2DM in both Caucasians and Asians, with Asians showing much higher risk of T2DM complications than Caucasians for the same. DISCUSSION: GSTM1 , GSTT1 and combined GSTM1 -GSTT1 null polymorphism may be associated with increased risk for T2DM; while GSTT1 and combined GSTM1 -GSTT1 null polymorphism may increase the risk of subsequent development of T2DM complications with Asian population carrying an amplified risk for the polymorphism. CONCLUSION: Thus GSTM1 and GSTT1 null genotypes increases the risk for Type 2 diabetes mellitus alone, in combination or with regards to ethnicity. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.
Entities: Disease
Gene
Keywords:
GSTM1; GSTT1; Genetic polymorphism; glutathione S-transferases; meta-analysis; type 2 diabetes mellitus.
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Substances： See more »
Year: 2019
PMID： 29243583 DOI： 10.2174/1573399814666171215120228
Source DB: PubMed Journal: Curr Diabetes Rev ISSN： 1573-3998