Literature DB >> 29242753

Activating transcription factor 3 in immune response and metabolic regulation.

Kavita Jadhav1, Yanqiao Zhang1.   

Abstract

Activating transcription factor 3 (ATF3) is a member of the ATF/cAMP-response element binding protein (CREB) family of transcription factors. In response to stress stimuli, ATF3 forms dimers to activate or repress gene expression. Further, ATF3 modulates the immune response, atherogenesis, cell cycle, apoptosis, and glucose homeostasis. Recent studies have shown that ATF3 may also be involved in pathogenesis of other diseases. However, more studies are needed to determine the role of ATF3 in metabolic regulation.

Entities:  

Keywords:  Activating transcription factor 3 (ATF3); Glucose homeostasis; Immune; Liver injury; Oncogenesis

Year:  2017        PMID： 29242753      PMCID： PMC5724780          DOI： 10.1016/j.livres.2017.08.001

Source DB:  PubMed          Journal:  Liver Res


  59 in total

1.  ATF3 expression in cardiomyocytes preserves homeostasis in the heart and controls peripheral glucose tolerance.

Authors:  Roy Kalfon; Lilach Koren; Sharon Aviram; Ortal Schwartz; Tsonwin Hai; Ami Aronheim
Journal:  Cardiovasc Res       Date:  2016-11-07       Impact factor: 10.787

2.  CREM gene: use of alternative DNA-binding domains generates multiple antagonists of cAMP-induced transcription.

Authors:  N S Foulkes; E Borrelli; P Sassone-Corsi
Journal:  Cell       Date:  1991-02-22       Impact factor: 41.582

3.  ATF3 Inhibits Tenascin-C-induced Foam Cell Formation in LPS-Stimulated THP-1 Macrophages by Suppressing TLR-4.

Authors:  Hong Luo; Jing Wang; Chenhui Qiao; Xin Zhang; Weihua Zhang; Ning Ma
Journal:  J Atheroscler Thromb       Date:  2015-06-30       Impact factor: 4.928

4.  Activation of ER stress and mTORC1 suppresses hepatic sortilin-1 levels in obese mice.

Authors:  Ding Ai; Juan M Baez; Hongfeng Jiang; Donna M Conlon; Antonio Hernandez-Ono; Maria Frank-Kamenetsky; Stuart Milstein; Kevin Fitzgerald; Andrew J Murphy; Connie W Woo; Alanna Strong; Henry N Ginsberg; Ira Tabas; Daniel J Rader; Alan R Tall
Journal:  J Clin Invest       Date:  2012-04-02       Impact factor: 14.808

5.  The roles of ATF3, an adaptive-response gene, in high-fat-diet-induced diabetes and pancreatic beta-cell dysfunction.

Authors:  Erik J Zmuda; Ling Qi; Michael X Zhu; Raghavendra G Mirmira; Marc R Montminy; Tsonwin Hai
Journal:  Mol Endocrinol       Date:  2010-06-02

6.  Role for activating transcription factor 3 in stress-induced beta-cell apoptosis.

Authors:  Matthew G Hartman; Dan Lu; Mi-Lyang Kim; Gary J Kociba; Tala Shukri; Jean Buteau; Xiaozhong Wang; Wendy L Frankel; Denis Guttridge; Marc Prentki; Shane T Grey; David Ron; Tsonwin Hai
Journal:  Mol Cell Biol       Date:  2004-07       Impact factor: 4.272

7.  NF-κB1 inhibits NOD2-induced cytokine secretion through ATF3-dependent mechanisms.

Authors:  Shasha Zheng; Clara Abraham
Journal:  Mol Cell Biol       Date:  2013-10-07       Impact factor: 4.272

8.  ATF3 expression is induced by low glucose in pancreatic α and β cells and regulates glucagon but not insulin gene transcription.

Authors:  Yong-Soo Lee; Masaki Kobayashi; Osamu Kikuchi; Tsutomu Sasaki; Hiromi Yokota-Hashimoto; Vina Yanti Susanti; Yukari Ido Kitamura; Tadahiro Kitamura
Journal:  Endocr J       Date:  2013-10-20       Impact factor: 2.349

9.  ATF3 protects against atherosclerosis by suppressing 25-hydroxycholesterol-induced lipid body formation.

Authors:  Elizabeth S Gold; Stephen A Ramsey; Mark J Sartain; Jyrki Selinummi; Irina Podolsky; David J Rodriguez; Robert L Moritz; Alan Aderem
Journal:  J Exp Med       Date:  2012-04-02       Impact factor: 14.307

10.  The transcription factor ATF3 acts as an oncogene in mouse mammary tumorigenesis.

Authors:  Aijin Wang; Stacey Arantes; Leqin Yan; Kaoru Kiguchi; Mark J McArthur; Aysegul Sahin; Howard D Thames; C Marcelo Aldaz; Michael C Macleod
Journal:  BMC Cancer       Date:  2008-09-22       Impact factor: 4.430
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  20 in total

1.  TRIB1 regulates LDL metabolism through CEBPα-mediated effects on the LDL receptor in hepatocytes.

Authors:  Katherine Quiroz-Figueroa; Cecilia Vitali; Donna M Conlon; John S Millar; John W Tobias; Robert C Bauer; Nicholas J Hand; Daniel J Rader
Journal:  J Clin Invest       Date:  2021-11-15       Impact factor: 14.808

Review 2.  ATF3 in atherosclerosis: a controversial transcription factor.

Authors:  Bingyu Wang; Xi Yang; Xinyi Sun; Jianhui Liu; Yin Fu; Bingyang Liu; Jun Qiu; Jiangfang Lian; Jianqing Zhou
Journal:  J Mol Med (Berl)       Date:  2022-10-08       Impact factor: 5.606

3.  Editorial: Local Immune Modulation of Macrophages and Dendritic Cells - Local Matters.

Authors:  Felix Bock; Daniel Saban; Alexander Steinkasserer
Journal:  Front Immunol       Date:  2022-06-27       Impact factor: 8.786

4.  Multi-Omics Reveals Impact of Cysteine Feed Concentration and Resulting Redox Imbalance on Cellular Energy Metabolism and Specific Productivity in CHO Cell Bioprocessing.

Authors:  Amr S Ali; Rachel Chen; Ravali Raju; Rashmi Kshirsagar; Alan Gilbert; Li Zang; Barry L Karger; Alexander R Ivanov
Journal:  Biotechnol J       Date:  2020-04-03       Impact factor: 4.677

5.  The mRNA levels of heat shock factor 1 are regulated by thermogenic signals via the cAMP-dependent transcription factor ATF3.

Authors:  Narendra Verma; Luce Perie; Elisabetta Mueller
Journal:  J Biol Chem       Date:  2020-03-17       Impact factor: 5.157

6.  ATF-3 expression inhibits melanoma growth by downregulating ERK and AKT pathways.

Authors:  Tingjian Zu; Diana Wang; Shuyun Xu; Catherine A A Lee; Ellen Zhen; Charles H Yoon; Phammela Abarzua; Shuangshuang Wang; Natasha Y Frank; Xunwei Wu; Christine G Lian; George F Murphy
Journal:  Lab Invest       Date:  2020-12-09       Impact factor: 5.662

7.  Epigenetic programming underpins B cell dysfunction in human SLE.

Authors:  Christopher D Scharer; Emily L Blalock; Tian Mi; Benjamin G Barwick; Scott A Jenks; Tsuneo Deguchi; Kevin S Cashman; Bridget E Neary; Dillon G Patterson; Sakeenah L Hicks; Arezou Khosroshahi; F Eun-Hyung Lee; Chungwen Wei; Iñaki Sanz; Jeremy M Boss
Journal:  Nat Immunol       Date:  2019-07-01       Impact factor: 25.606

8.  Chronic Liver Disease in Humans Causes Expansion and Differentiation of Liver Lymphatic Endothelial Cells.

Authors:  Beth A Jiron Tamburini; Jeffrey M Finlon; Austin E Gillen; Michael S Kriss; Kent A Riemondy; Rui Fu; Ronald P Schuyler; Jay R Hesselberth; Hugo R Rosen; Matthew A Burchill
Journal:  Front Immunol       Date:  2019-05-15       Impact factor: 7.561

9.  Comparative host interactomes of the SARS-CoV-2 nonstructural protein 3 and human coronavirus homologs.

Authors:  Katherine M Almasy; Jonathan P Davies; Lars Plate
Journal:  bioRxiv       Date:  2021-03-08

10.  Eater cooperates with Multiplexin to drive the formation of hematopoietic compartments.

Authors:  Gábor Csordás; Ferdinand Grawe; Mirka Uhlirova
Journal:  Elife       Date:  2020-10-07       Impact factor: 8.140
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