Literature DB >> 29242029

Modernizing Human Cancer Risk Assessment of Therapeutics.

Mark R Fielden1, Lucas D Ward2, Sheroy Minocherhomji2, Paul Nioi2, Herve Lebrec2, David Jacobson-Kram3.   

Abstract

Cancer risk assessment of therapeutics is plagued by poor translatability of rodent models of carcinogenesis. In order to overcome this fundamental limitation, new approaches are needed that enable us to evaluate cancer risk directly in humans and human-based cellular models. Our enhanced understanding of the mechanisms of carcinogenesis and the influence of human genome sequence variation on cancer risk motivates us to re-evaluate how we assess the carcinogenic risk of therapeutics. This review will highlight new opportunities for applying this knowledge to the development of a battery of human-based in vitro models and biomarkers for assessing cancer risk of novel therapeutics.
Copyright © 2017 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  carcinogenicity; genome-wide association studies; genomic instability; human biomarkers; next-generation sequencing; replication stress

Mesh：

Substances：

Year:  2017        PMID： 29242029     DOI： 10.1016/j.tips.2017.11.005

Source DB:  PubMed          Journal:  Trends Pharmacol Sci        ISSN： 0165-6147            Impact factor:   14.819


  9 in total

Review 1.  Enhancing the accuracy of next-generation sequencing for detecting rare and subclonal mutations.

Authors:  Jesse J Salk; Michael W Schmitt; Lawrence A Loeb
Journal:  Nat Rev Genet       Date:  2018-03-26       Impact factor: 53.242

2.  A cross-sector call to improve carcinogenicity risk assessment through use of genomic methodologies.

Authors:  Carole L Yauk; Alison H Harrill; Heidrun Ellinger-Ziegelbauer; Jan Willem van der Laan; Jonathan Moggs; Roland Froetschl; Frank Sistare; Syril Pettit
Journal:  Regul Toxicol Pharmacol       Date:  2019-11-11       Impact factor: 3.271

Review 3.  Using human genetics to improve safety assessment of therapeutics.

Authors:  Keren J Carss; Aimee M Deaton; Alberto Del Rio-Espinola; Dorothée Diogo; Mark Fielden; Diptee A Kulkarni; Jonathan Moggs; Peter Newham; Matthew R Nelson; Frank D Sistare; Lucas D Ward; Jing Yuan
Journal:  Nat Rev Drug Discov       Date:  2022-10-19       Impact factor: 112.288

4.  Application of the key characteristics of carcinogens in cancer hazard identification.

Authors:  Kathryn Z Guyton; Ivan Rusyn; Weihsueh A Chiu; Denis E Corpet; Martin van den Berg; Matthew K Ross; David C Christiani; Frederick A Beland; Martyn T Smith
Journal:  Carcinogenesis       Date:  2018-04-05       Impact factor: 4.944

5.  Re: 'Application of the key characteristics of carcinogens in cancer hazard evaluation': response to Goodman, Lynch and Rhomberg.

Authors:  Kathryn Z Guyton; Ivan Rusyn; Weihsueh A Chiu; Denis E Corpet; Martin van den Berg; Matthew K Ross; David C Christiani; Frederick A Beland; Martyn T Smith
Journal:  Carcinogenesis       Date:  2018-07-30       Impact factor: 4.944

6.  Key Characteristics of Cardiovascular Toxicants.

Authors:  Lars Lind; Jesus A Araujo; Aaron Barchowsky; Scott Belcher; Brian R Berridge; Nipavan Chiamvimonvat; Weihsueh A Chiu; Vincent J Cogliano; Sarah Elmore; Aimen K Farraj; Aldrin V Gomes; Cliona M McHale; Kathleen B Meyer-Tamaki; Nikki Gillum Posnack; Hugo M Vargas; Xi Yang; Lauren Zeise; Changcheng Zhou; Martyn T Smith
Journal:  Environ Health Perspect       Date:  2021-09-24       Impact factor: 9.031

7.  Linking Pollutants and Therapeutics to Heart Health: Key Characteristics of Cardiovascular Toxicants.

Authors:  Silke Schmidt
Journal:  Environ Health Perspect       Date:  2021-11-19       Impact factor: 9.031

8.  Consensus on the Key Characteristics of Immunotoxic Agents as a Basis for Hazard Identification.

Authors:  Dori R Germolec; Herve Lebrec; Stacey E Anderson; Gary R Burleson; Andres Cardenas; Emanuela Corsini; Sarah E Elmore; Barbara L F Kaplan; B Paige Lawrence; Geniece M Lehmann; Curtis C Maier; Cliona M McHale; L Peyton Myers; Marc Pallardy; Andrew A Rooney; Lauren Zeise; Luoping Zhang; Martyn T Smith
Journal:  Environ Health Perspect       Date:  2022-10-06       Impact factor: 11.035

9.  Key Characteristics of Human Hepatotoxicants as a Basis for Identification and Characterization of the Causes of Liver Toxicity.

Authors:  Ivan Rusyn; Xabier Arzuaga; Russell C Cattley; J Christopher Corton; Stephen S Ferguson; Patricio Godoy; Kathryn Z Guyton; Neil Kaplowitz; Salman R Khetani; Ruth A Roberts; Robert A Roth; Martyn T Smith
Journal:  Hepatology       Date:  2021-07-13       Impact factor: 17.298
  9 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.