Literature DB >> 2924139

Depression of calcium current at mouse motor nerve endings by polycationic antibiotics.

C Bourret1, A Mallart.   

Abstract

The hypothesis according to which polycationic antibiotics produce neuromuscular block by interfering with the Ca current of motor nerve terminals has been examined using external electrodes in nerve-muscle preparations of the mouse. It was found that kanamycin, bekanamycin and polymyxin B depressed presynaptic Ca currents probably by neutralizing negative surface charges.

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Year:  1989        PMID： 2924139     DOI： 10.1016/0006-8993(89)91525-4

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  2 in total

1.  The efferent-mediated suppression of otoacoustic emissions in awake guinea pigs and its reversible blockage by gentamicin.

Authors:  P Avan; J P Erre; D L da Costa; J M Aran; J Popelár
Journal:  Exp Brain Res       Date:  1996-04       Impact factor: 1.972

2.  Inhibition of Ca2+ inflow at nerve terminals of frog muscle blocks facilitation while phasic transmitter release is still considerable.

Authors:  J Dudel
Journal:  Pflugers Arch       Date:  1990-02       Impact factor: 3.657
  2 in total

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