Literature DB >> 2924138

Functional muscarinic supersensitivity in denervated rat hippocampus.

D M Benson1, R D Blitzer, V Haroutunian, E M Landau.   

Abstract

The effects of carbachol (CCh), a cholinergic agonist, were compared in voltage-clamped hippocampal pyramidal neurons in vitro, obtained from normal and fimbria-fornix-lesioned rats. A substantial increase in sensitivity to the effects of CCh was seen in denervated neurons. The supersensitivity was demonstrated on both the inward leak current and the calcium-dependent potassium current, IAHP. These findings provide convincing evidence for cholinergic denervation supersensitivity in the hippocampus.

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Year:  1989        PMID： 2924138     DOI： 10.1016/0006-8993(89)91524-2

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  5 in total

1.  Muscarinic receptors mediating depression and long-term potentiation in rat hippocampus.

Authors:  J M Auerbach; M Segal
Journal:  J Physiol       Date:  1996-04-15       Impact factor: 5.182

2.  Long term effects of septohippocampal lesions and intrahippocampal grafts on acetylcholine concentration, muscarinic stimulated formation of inositol phospholipids and electrically evoked release of neurotransmitters in the rat hippocampus.

Authors:  J C Cassel; R Jackisch; M Duschek; J M Hornsperger; M H Richards; C Kelche; G Hertting; B Will
Journal:  Exp Brain Res       Date:  1991       Impact factor: 1.972

Review 3.  ACh Transfers: Homeostatic Plasticity of Cholinergic Synapses.

Authors:  Sarra Djemil; Antonia M Sames; Daniel T S Pak
Journal:  Cell Mol Neurobiol       Date:  2022-05-28       Impact factor: 5.046

4.  An iontophoretic study of the effects of alpha-amino-hydroxy-5-methyl-4-isoxazole propionic acid lesions of the nucleus basalis magnocellularis on cholinergic and GABAergic influences on frontal cortex neurones of rats.

Authors:  F A Abdulla; M R Calaminici; V V Raevsky; J D Sinden; J A Gray; J D Stephenson
Journal:  Exp Brain Res       Date:  1994       Impact factor: 1.972

Review 5.  Abnormalities of Dopamine D3 Receptor Signaling in the Diseased Brain.

Authors:  G Aleph Prieto
Journal:  J Cent Nerv Syst Dis       Date:  2017-08-16
  5 in total

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