Literature DB >> 2924114

Administration of L-2-oxothiazolidine-4-carboxylate increases glutathione levels in rat brain.

J E Mesina1, R H Page, F W Hetzel, M Chopp.   

Abstract

Sterile L-2-oxothiazolidine-4-carboxylate, given as a neutral 100 mmol solution at a dose of 8 mmol/kg subcutaneously, caused an increase in total glutathione concentration in the brain of treated rats. This finding could be important in understanding the role of glutathione in the central nervous system.

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Year:  1989        PMID： 2924114     DOI： 10.1016/0006-8993(89)91494-7

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  8 in total

1.  External cys/cySS redox state modification controls the intracellular redox state and neurodegeneration via Akt in aging and Alzheimer's disease mouse model neurons.

Authors:  Debolina Ghosh; Gregory J Brewer
Journal:  J Alzheimers Dis       Date:  2014       Impact factor: 4.472

2.  Non-invasive monitoring of L-2-oxothiazolidine-4-carboxylate metabolism in the rat brain by in vivo 13C magnetic resonance spectroscopy.

Authors:  Michael P Gamcsik; M Daniel Clark; Susan M Ludeman; James B Springer; Michael A D'Alessandro; Nicholas E Simpson; Roxana Pourdeyhimi; C Bryce Johnson; Stephanie D Teeter; Stephen J Blackband; Peter E Thelwall
Journal:  Neurochem Res       Date:  2010-12-15       Impact factor: 3.996

3.  Transport via SLC5A8 (SMCT1) is obligatory for 2-oxothiazolidine-4-carboxylate to enhance glutathione production in retinal pigment epithelial cells.

Authors:  Ellappan Babu; Sudha Ananth; Rajalakshmi Veeranan-Karmegam; Veena Coothankandaswamy; Sylvia B Smith; Thomas Boettger; Vadivel Ganapathy; Pamela M Martin
Journal:  Invest Ophthalmol Vis Sci       Date:  2011-07-29       Impact factor: 4.799

4.  Thioctic acid does not restore glutathione levels or protect against the potentiation of 6-hydroxydopamine toxicity induced by glutathione depletion in rat brain.

Authors:  T A Seaton; P Jenner; C D Marsden
Journal:  J Neural Transm (Vienna)       Date:  1996       Impact factor: 3.575

Review 5.  Cysteine Donor-Based Brain-Targeting Prodrug: Opportunities and Challenges.

Authors:  Gaoyang Ni; Zhenbiao Hu; Ziteng Wang; Min Zhang; Xingyu Liu; Guihong Yang; Zhaowei Yan; Yang Zhang
Journal:  Oxid Med Cell Longev       Date:  2022-02-24       Impact factor: 6.543

6.  Arginine Thiazolidine Carboxylate Stimulates Insulin Secretion through Production of Ca2+-Mobilizing Second Messengers NAADP and cADPR in Pancreatic Islets.

Authors:  Dae-Ryoung Park; Asif Iqbal Shawl; Tae-Geun Ha; Kwang-Hyun Park; Seon-Young Kim; Uh-Hyun Kim
Journal:  PLoS One       Date:  2015-08-06       Impact factor: 3.240

7.  L-2-oxothiazolidine-4-carboxylic acid attenuates oxidative stress and inflammation in retinal pigment epithelium.

Authors:  Wanwisa Promsote; Rajalakshmi Veeranan-Karmegam; Sudha Ananth; Defen Shen; Chi-Chao Chan; Nevin A Lambert; Vadivel Ganapathy; Pamela M Martin
Journal:  Mol Vis       Date:  2014-01-07       Impact factor: 2.367

8.  Nutritional regulation of glutathione in stroke.

Authors:  P G Paterson; B H Juurlink
Journal:  Neurotox Res       Date:  1999-12       Impact factor: 3.911
  8 in total

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