Yi Xie1, Yongfu Shao2, Weiliang Sun3, Guoliang Ye2, Xinjun Zhang2, Bingxiu Xiao1, Junming Guo1. 1. Department of Biochemistry & Molecular Biology, & Zhejiang Key Laboratory of Pathophysiology, Medical School of Ningbo University, Ningbo 315211, PR China. 2. Department of Gastroenterology, the Affiliated Hospital of Medical School of Ningbo University, Ningbo 315020, PR China. 3. Ningbo Yinzhou People's Hospital & the Affiliated Hospital, Medical School of Ningbo University, Ningbo 315040, PR China.
Abstract
AIM: To explore the diagnostic value of hsa_circ_0074362 in the screening of gastric cancer. METHODS: The expression levels of hsa_circ_0074362 in 127 gastric cancer tissues and paired adjacent normal tissues, 83 gastritis tissues and six gastric cancer cell lines were first detected by quantitative reverse transcription-polymerase chain reaction. Then, the relationship between its levels and clinicopathological factors of patients with gastric cancer was analyzed. Finally, a receiver operating characteristic curve was established. RESULTS: Hsa_circ_0074362 levels were significantly downregulated in gastric cancer tissues, gastritis tissues and gastric cancer cell lines. Its levels were associated with lymphatic metastasis. CONCLUSION: Hsa_circ_0074362 probably plays a role in the initiation of gastric cancer and may be a potential biomarker of gastric cancer.
AIM: To explore the diagnostic value of hsa_circ_0074362 in the screening of gastric cancer. METHODS: The expression levels of hsa_circ_0074362 in 127 gastric cancer tissues and paired adjacent normal tissues, 83 gastritis tissues and six gastric cancer cell lines were first detected by quantitative reverse transcription-polymerase chain reaction. Then, the relationship between its levels and clinicopathological factors of patients with gastric cancer was analyzed. Finally, a receiver operating characteristic curve was established. RESULTS: Hsa_circ_0074362 levels were significantly downregulated in gastric cancer tissues, gastritis tissues and gastric cancer cell lines. Its levels were associated with lymphatic metastasis. CONCLUSION: Hsa_circ_0074362 probably plays a role in the initiation of gastric cancer and may be a potential biomarker of gastric cancer.