Pietro Gentile1, Maria Giovanna Scioli2, Alessandra Bielli2, Augusto Orlandi2, Valerio Cervelli1. 1. Plastic & Reconstructive Surgery, Department of Biomedicine & Prevention, University of Rome 'Tor Vergata', Rome, Italy. 2. Department of Biomedicine & Prevention, Anatomic Pathology Institute, University of Rome 'Tor Vergata', Rome, Italy.
Abstract
AIM: Recently, a new fat grafting technique termed 'nanofat grafting' was proposed which improved tissue repair by the stem cells contained in the stromal vascular fraction (SVF) of nanofat. Here, we reported the clinical outcomes of different nanofat procedures in the treatment of scars in relation with SVF cell yield. METHODS: Three different modified nanofat grafting procedures (supercharged-, evo- and centrifuged-modified nanofat) were compared with the classic nanofat method, and histological analysis was performed to assess skin regeneration. Residual nanofat samples were analyzed to determine SVF immunophenotype and yield from each procedure. RESULTS: Supercharged-modified nanofat gave the best results in terms of clinical outcome and SVF yield. Histological analysis revealed similar skin regeneration in all treatments. CONCLUSION: This work suggested a positive correlation between SVF yield and clinical outcomes in the nanofat treatment of scars.
AIM: Recently, a new fat grafting technique termed 'nanofat grafting' was proposed which improved tissue repair by the stem cells contained in the stromal vascular fraction (SVF) of nanofat. Here, we reported the clinical outcomes of different nanofat procedures in the treatment of scars in relation with SVF cell yield. METHODS: Three different modified nanofat grafting procedures (supercharged-, evo- and centrifuged-modified nanofat) were compared with the classic nanofat method, and histological analysis was performed to assess skin regeneration. Residual nanofat samples were analyzed to determine SVF immunophenotype and yield from each procedure. RESULTS: Supercharged-modified nanofat gave the best results in terms of clinical outcome and SVF yield. Histological analysis revealed similar skin regeneration in all treatments. CONCLUSION: This work suggested a positive correlation between SVF yield and clinical outcomes in the nanofat treatment of scars.
Authors: David M Burmeister; Grace Chu-Yuan Chu; Tony Chao; Tiffany C Heard; Belinda I Gómez; Linda E Sousse; Shanmugasundaram Natesan; Robert J Christy Journal: Stem Cell Res Ther Date: 2021-05-06 Impact factor: 6.832
Authors: Nesrine Ebrahim; Arigue A Dessouky; Ola Mostafa; Amira Hassouna; Mohamed M Yousef; Yasmin Seleem; Eman Abd El Aziz M El Gebaly; Mona M Allam; Ayman Samir Farid; Bayan A Saffaf; Dina Sabry; Ahmed Nawar; Ahmed A Shoulah; Ahmed H Khalil; Sami F Abdalla; Mohamed El-Sherbiny; Nehal M Elsherbiny; Rabab F Salim Journal: Stem Cell Res Ther Date: 2021-07-13 Impact factor: 6.832