Literature DB >> 2923621

The cDNA-derived amino acid sequence of chick heat shock protein Mr 90,000 (HSP 90) reveals a "DNA like" structure: potential site of interaction with steroid receptors.

N Binart1, B Chambraud, B Dumas, D A Rowlands, C Bigogne, J M Levin, J Garnier, E E Baulieu, M G Catelli.   

Abstract

We report cDNA sequence, the complete derived aa sequence, and a predicted secondary structure of the chick hsp 90, a protein which has been found to form complexes with steroid hormone receptors. The modelling of the most negatively charged "region A" indicates that the alpha-helices of this portion of hsp 90 mimick DNA configuration. We propose that this region can, in absence of hormone, interact with and cap the positively charged DNA-binding domain of steroid receptors.

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Year:  1989        PMID： 2923621     DOI： 10.1016/0006-291x(89)92415-7

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  7 in total

1.  Isolation and functional analysis of chicken 90-kDa heat shock protein gene promoter.

Authors:  C Vourc'h; N Binart; B Chambraud; J P David; V Jérôme; E E Baulieu; M G Catelli
Journal:  Nucleic Acids Res       Date:  1989-07-11       Impact factor: 16.971

2.  Arachidonic acid metabolism in heat-shock treated human leucocytes.

Authors:  M Köller; W König
Journal:  Immunology       Date:  1990-08       Impact factor: 7.397

3.  Distinct functions of the 90 kDa heat-shock protein (hsp90) in oestrogen and mineralocorticosteroid receptor activity: effects of hsp90 deletion mutants.

Authors:  N Binart; M Lombès; E E Baulieu
Journal:  Biochem J       Date:  1995-11-01       Impact factor: 3.857

4.  Interaction of glucocorticosteroid receptor and wild-type or mutated 90-kDa heat shock protein coexpressed in baculovirus-infected Sf9 cells.

Authors:  F Cadepond; N Binart; B Chambraud; N Jibard; G Schweizer-Groyer; I Segard-Maurel; E E Baulieu
Journal:  Proc Natl Acad Sci U S A       Date:  1993-11-15       Impact factor: 11.205

5.  In vivo functional protein-protein interaction: nuclear targeted hsp90 shifts cytoplasmic steroid receptor mutants into the nucleus.

Authors:  K I Kang; J Devin; F Cadepond; N Jibard; A Guiochon-Mantel; E E Baulieu; M G Catelli
Journal:  Proc Natl Acad Sci U S A       Date:  1994-01-04       Impact factor: 11.205

6.  Identification of the pentapeptide constituting a dominant epitope common to all eukaryotic heat shock protein 90 molecular chaperones.

Authors:  Jun Kishimoto; Yutaka Fukuma; Akio Mizuno; Takayuki K Nemoto
Journal:  Cell Stress Chaperones       Date:  2005       Impact factor: 3.667

7.  Interaction of vault particles with estrogen receptor in the MCF-7 breast cancer cell.

Authors:  C Abbondanza; V Rossi; A Roscigno; L Gallo; A Belsito; G Piluso; N Medici; V Nigro; A M Molinari; B Moncharmont; G A Puca
Journal:  J Cell Biol       Date:  1998-06-15       Impact factor: 10.539
  7 in total

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