Rosa Ayesa-Arriola1,2, Manuel Canal Rivero1,2, Manuel Delgado-Alvarado2,3, Esther Setién-Suero1,2, Jana González-Gómez1, Javier Labad2,4, Anthony S David5, Benedicto Crespo-Facorro1,2. 1. a Department of Psychiatry , Marqués de Valdecilla University Hospital, IDIVAL, School of Medicine, University of Cantabria , Santander , Spain. 2. b CIBERSAM, Centro Investigación Biomédica en Red Salud Mental , Spain. 3. c Neurology Department, Neuroimaging Unit , Marqués de Valdecilla University Hospital. Valdecilla Biomedical Research Institute, IDIVAL , Santander , Spain. 4. d Department of Psychiatry , Corporació Sanitària Universitaria Parc Taulí, I3PT, UAB , Sabadell , Spain. 5. e Department of Psychosis Studies. Institute of Psychiatry , King's College London , London , UK.
Abstract
OBJECTIVES: Our aims were to confirm the relationship between lipid and lipoprotein concentrations and suicidal behaviour in first-episode psychosis (FEP) patients. METHODS: Suicidal behaviour was explored in a large FEP sample (N = 383). Baseline lipid profile was compared between those who attempted or completed suicide and those who not presented suicidal behaviour. RESULTS: Low-density lipoprotein cholesterol (LDL-c) (OR = 0.99, 95% CI= 0.98-1.00) and depressive symptoms (OR = 1.15, 95% CI = 1.06-1.24) were significantly related with suicidal behaviour. CONCLUSIONS: Lipid profile test may be considered in the assessment of suicide risk in psychosis and LDL-c an important biological marker.
OBJECTIVES: Our aims were to confirm the relationship between lipid and lipoprotein concentrations and suicidal behaviour in first-episode psychosis (FEP) patients. METHODS: Suicidal behaviour was explored in a large FEP sample (N = 383). Baseline lipid profile was compared between those who attempted or completed suicide and those who not presented suicidal behaviour. RESULTS:Low-density lipoprotein cholesterol (LDL-c) (OR = 0.99, 95% CI= 0.98-1.00) and depressive symptoms (OR = 1.15, 95% CI = 1.06-1.24) were significantly related with suicidal behaviour. CONCLUSIONS:Lipid profile test may be considered in the assessment of suicide risk in psychosis and LDL-c an important biological marker.
Authors: Jenessa N Johnston; Darcy Campbell; Hector J Caruncho; Ioline D Henter; Elizabeth D Ballard; Carlos A Zarate Journal: Int J Neuropsychopharmacol Date: 2022-03-17 Impact factor: 5.176
Authors: Jason D Cooper; Sung Yeon Sarah Han; Jakub Tomasik; Sureyya Ozcan; Nitin Rustogi; Nico J M van Beveren; F Markus Leweke; Sabine Bahn Journal: Transl Psychiatry Date: 2019-02-11 Impact factor: 6.222