Sigurdur S Stephensen1,2, Ellen Ostenfeld1, Katarina Steding-Ehrenborg1,3, Ulf Thilén4, Einar Heiberg1,5, Hakan Arheden1, Marcus Carlsson1. 1. Department of Clinical Sciences, Clinical Physiology, Lund University, Lund, Sweden. 2. Department of Pediatric Cardiology, Lund University Hospital, Lund University, Lund, Sweden. 3. Department of Health Sciences, Physiotherapy, Lund University, Lund, Sweden. 4. Department of Cardiology, Lund University Hospital, Lund University, Lund, Sweden. 5. Department of Biomedical Engineering, Faculty of Engineering, Lund University, Lund, Sweden.
Abstract
BACKGROUND: Regional ventricular pumping mechanisms in patients with volume-loaded right ventricles (RV) are altered, but the cause is unknown. The aim was to determine whether these changes in ventricular pumping mechanisms are influenced by the RV dilatation itself or the aetiology behind it. METHODS: Seventeen patients with atrial septal defects (ASD) and 10 healthy controls underwent cardiovascular magnetic resonance (CMR) at rest and during dobutamine/atropine stress. Sixteen patients underwent transcutaneous ASD closure. Follow-up CMR at rest was performed the following day. Thirty patients with RV overload due to pulmonary regurgitation (PR) underwent CMR at rest. Cine images were used to measure left ventricular (LV) and RV volumes as well as septal, longitudinal and lateral contributions to LV and RV stroke volume (SV). RESULTS: At rest, septal contribution to LVSV was lower in ASD patients than controls (-1% versus 7%, P<0·05), but there was no difference in longitudinal or lateral contribution to SV. Patients with PR had lower longitudinal contribution to RV with increased lateral and septal contribution. During dobutamine stress, longitudinal contribution to LV and RVSV decreased and lateral contribution increased for ASD patients and controls. The day after ASD closure, septal contribution to LVSV was 6%, longitudinal contribution had increased for RVSV (P<0·05) and decreased for LVSV (P<0·01). CONCLUSION: Pumping mechanisms in patients with RV volume overload depend on the aetiology for the RV dilation and not the size of the RV.
BACKGROUND: Regional ventricular pumping mechanisms in patients with volume-loaded right ventricles (RV) are altered, but the cause is unknown. The aim was to determine whether these changes in ventricular pumping mechanisms are influenced by the RV dilatation itself or the aetiology behind it. METHODS: Seventeen patients with atrial septal defects (ASD) and 10 healthy controls underwent cardiovascular magnetic resonance (CMR) at rest and during dobutamine/atropine stress. Sixteen patients underwent transcutaneous ASD closure. Follow-up CMR at rest was performed the following day. Thirty patients with RV overload due to pulmonary regurgitation (PR) underwent CMR at rest. Cine images were used to measure left ventricular (LV) and RV volumes as well as septal, longitudinal and lateral contributions to LV and RV stroke volume (SV). RESULTS: At rest, septal contribution to LVSV was lower in ASDpatients than controls (-1% versus 7%, P<0·05), but there was no difference in longitudinal or lateral contribution to SV. Patients with PR had lower longitudinal contribution to RV with increased lateral and septal contribution. During dobutamine stress, longitudinal contribution to LV and RVSV decreased and lateral contribution increased for ASDpatients and controls. The day after ASD closure, septal contribution to LVSV was 6%, longitudinal contribution had increased for RVSV (P<0·05) and decreased for LVSV (P<0·01). CONCLUSION: Pumping mechanisms in patients with RV volume overload depend on the aetiology for the RV dilation and not the size of the RV.
Authors: Ricardo A Gonzales; Felicia Seemann; Jérôme Lamy; Hamid Mojibian; Dan Atar; David Erlinge; Katarina Steding-Ehrenborg; Håkan Arheden; Chenxi Hu; John A Onofrey; Dana C Peters; Einar Heiberg Journal: J Cardiovasc Magn Reson Date: 2021-12-02 Impact factor: 5.364
Authors: Björn Östenson; Ellen Ostenfeld; Anna Werther-Evaldsson; Anders Roijer; Zoltan Bakos; Mikael Kanski; Einar Heiberg; Håkan Arheden; Rasmus Borgquist; Marcus Carlsson Journal: BMC Cardiovasc Disord Date: 2021-10-26 Impact factor: 2.298
Authors: Anna Werther Evaldsson; Anthony Lindholm; Raluca Jumatate; Annika Ingvarsson; Gustav Jan Smith; Johan Waktare; Göran Rådegran; Anders Roijer; Carl Meurling; Ellen Ostenfeld Journal: BMC Cardiovasc Disord Date: 2020-06-01 Impact factor: 2.298