BACKGROUND: Focal adhesion kinase (FAK) is a cytoplasmic tyrosine kinase that plays an important role as a mediator of cell migration, invasion, proliferation and survival. Conflicting results for the prognostic role of FAK in breast cancer (BC) prompted us to determine its impact. METHODS: Patients with node-negative BC entered this retrospective study. FAK expression was determined by immunohistochemistry (n = 335). The prognostic impact of FAK was examined with Cox regression analyses and Kaplan-Meier estimation in the whole cohort as well as in different molecular subtypes. RESULTS: 151 (45.1%) had a FAK-positive BC. In univariate analyses, FAK expression showed a significant impact for shorter disease-free survival (DFS) (hazard ratio (HR) 1.54, 95% confidence interval (CI) 1.04-2.28, p = 0.030) but not for metastasis-free survival and overall survival. Significant prognostic relevance for DFS (HR 1.76, 95% CI 1.05-2.97, p = 0.033) was observed in particular in estrogen receptor-positive HER2-negative BC patients, most notably in luminal B-like tumors (HR 2.32, CI 1.20-4.48, p = 0.012). However, FAK lost its prognostic impact in multivariate Cox regression analysis. CONCLUSION: FAK was associated with impaired DFS in univariate analysis. Prognostic relevance for DFS was most pronounced in luminal B-like BC. However, FAK expression was not associated with an independent impact on survival for BC in multivariate analysis.
BACKGROUND: Focal adhesion kinase (FAK) is a cytoplasmic tyrosine kinase that plays an important role as a mediator of cell migration, invasion, proliferation and survival. Conflicting results for the prognostic role of FAK in breast cancer (BC) prompted us to determine its impact. METHODS: Patients with node-negative BC entered this retrospective study. FAK expression was determined by immunohistochemistry (n = 335). The prognostic impact of FAK was examined with Cox regression analyses and Kaplan-Meier estimation in the whole cohort as well as in different molecular subtypes. RESULTS: 151 (45.1%) had a FAK-positive BC. In univariate analyses, FAK expression showed a significant impact for shorter disease-free survival (DFS) (hazard ratio (HR) 1.54, 95% confidence interval (CI) 1.04-2.28, p = 0.030) but not for metastasis-free survival and overall survival. Significant prognostic relevance for DFS (HR 1.76, 95% CI 1.05-2.97, p = 0.033) was observed in particular in estrogen receptor-positive HER2-negative BC patients, most notably in luminal B-like tumors (HR 2.32, CI 1.20-4.48, p = 0.012). However, FAK lost its prognostic impact in multivariate Cox regression analysis. CONCLUSION: FAK was associated with impaired DFS in univariate analysis. Prognostic relevance for DFS was most pronounced in luminal B-like BC. However, FAK expression was not associated with an independent impact on survival for BC in multivariate analysis.
Entities:
Keywords:
Breast cancer; Focal adhesion kinase; Node-negative; Prognosis; Protein
Authors: Harry M Lightfoot; Amy Lark; Chad A Livasy; Dominic T Moore; David Cowan; Lynn Dressler; Rolf J Craven; William G Cance Journal: Breast Cancer Res Treat Date: 2004-11 Impact factor: 4.872
Authors: Vita M Golubovskaya; Lourdes Ylagan; Austin Miller; Melissa Hughes; Jason Wilson; David Wang; Elizabeth Brese; Wiam Bshara; Stephen Edge; Carl Morrison; William G Cance Journal: BMC Cancer Date: 2014-10-17 Impact factor: 4.430
Authors: Klaus Jürgen Schmitz; Florian Grabellus; Rainer Callies; Friedrich Otterbach; Jeremias Wohlschlaeger; Bodo Levkau; Rainer Kimmig; Kurt Werner Schmid; Hideo Andreas Baba Journal: Breast Cancer Res Date: 2005-01-07 Impact factor: 6.466
Authors: M H A M van Miltenburg; M J van Nimwegen; I Tijdens; R Lalai; R Kuiper; S Klarenbeek; P C Schouten; A de Vries; J Jonkers; B van de Water Journal: Br J Cancer Date: 2014-05-08 Impact factor: 7.640
Authors: Jorge A Belgodere; Connor T King; Jacob B Bursavich; Matthew E Burow; Elizabeth C Martin; Jangwook P Jung Journal: Front Bioeng Biotechnol Date: 2018-05-24
Authors: Marina Roy-Luzarraga; Tarek Abdel-Fatah; Louise E Reynolds; Andrew Clear; Joseph G Taylor; John G Gribben; Stephen Chan; Louise Jones; Kairbaan Hodivala-Dilke Journal: JAMA Netw Open Date: 2020-10-01