Literature DB >> 29233768

Vaccine development targeting lipopolysaccharide structure modification.

Yun Zhao1, Vilma Arce-Gorvel1, Raquel Conde-Álvarez2, Ignacio Moriyon2, Jean-Pierre Gorvel3.   

Abstract

Vaccines are one of the most important methods for preventing infectious disease. Structural modification of lipopolysaccharide (LPS) provides a strategy for the development of live attenuated vaccines, either by altering the immunogenicity or by attenuating virulence of the bacteria. This review summarizes various approaches that utilize LPS mutants as whole-cell vaccines.
Copyright © 2017 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.

Entities:  

Keywords:  Brucella; Lipopolysaccharide; Vaccine

Mesh：

Substances：

Year:  2017        PMID： 29233768     DOI： 10.1016/j.micinf.2017.11.006

Source DB:  PubMed          Journal:  Microbes Infect        ISSN： 1286-4579            Impact factor:   2.700


  5 in total

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4.  T6SS secretes an LPS-binding effector to recruit OMVs for exploitative competition and horizontal gene transfer.

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5.  Brucella melitensis Wzm/Wzt System: Changes in the Bacterial Envelope Lead to Improved Rev1Δwzm Vaccine Properties.

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  5 in total

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