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Literature DB >> 29233267

Discovery and development of SV2A PET tracers: Potential for imaging synaptic density and clinical applications.

Joel Mercier¹, Laurent Provins², Anne Valade².

Abstract

Imaging synaptic density in vivo has promise for numerous research and clinical applications in the diagnosis and treatment monitoring of neurodegenerative and psychiatric diseases. Recent developments in the field of PET, such as SV2A human imaging with the novel tracers UCB-A, UCB-H and UCB-J, may help in realizing this potential and bring significant benefit for the patients suffering from these diseases. This review provides an overview of the most recent progress in the field of SV2A PET imaging, its potential for use as a biomarker of synaptic density and the future development areas.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 2017 PMID： 29233267 DOI： 10.1016/j.ddtec.2017.11.003

Source DB: PubMed Journal: Drug Discov Today Technol ISSN： 1740-6749

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Cited

14 in total

1. Quantification of [¹⁸F]UCB-H Binding in the Rat Brain: From Kinetic Modelling to Standardised Uptake Value.

Authors: Maria Elisa Serrano; Mohamed Ali Bahri; Guillaume Becker; Alain Seret; Frédéric Mievis; Fabrice Giacomelli; Christian Lemaire; Eric Salmon; André Luxen; Alain Plenevaux
Journal: Mol Imaging Biol Date: 2019-10 Impact factor: 3.488

2. Development and In Vivo Preclinical Imaging of Fluorine-18-Labeled Synaptic Vesicle Protein 2A (SV2A) PET Tracers.

Authors: Cristian C Constantinescu; Cedric Tresse; MingQiang Zheng; Alexandra Gouasmat; Vincent M Carroll; Laetitia Mistico; David Alagille; Christine M Sandiego; Caroline Papin; Kenneth Marek; John P Seibyl; Gilles D Tamagnan; Olivier Barret
Journal: Mol Imaging Biol Date: 2019-06 Impact factor: 3.488

Review 3. Neuroimaging Biomarkers for Alzheimer's Disease.

Authors: Freddie Márquez; Michael A Yassa
Journal: Mol Neurodegener Date: 2019-06-07 Impact factor: 14.195

4. A single-center, open-label positron emission tomography study to evaluate brivaracetam and levetiracetam synaptic vesicle glycoprotein 2A binding in healthy volunteers.

Authors: Sjoerd J Finnema; Samantha Rossano; Mika Naganawa; Shannan Henry; Hong Gao; Richard Pracitto; Ralph P Maguire; Joël Mercier; Sophie Kervyn; Jean-Marie Nicolas; Henrik Klitgaard; Steven DeBruyn; Christian Otoul; Paul Martin; Pierandrea Muglia; David Matuskey; Nabeel B Nabulsi; Yiyun Huang; Rafal M Kaminski; Jonas Hannestad; Armel Stockis; Richard E Carson
Journal: Epilepsia Date: 2019-03-29 Impact factor: 5.864

5. Late-Stage ¹⁸ F-Difluoromethyl Labeling of N-Heteroaromatics with High Molar Activity for PET Imaging.

Authors: Laura Trump; Agostinho Lemos; Bénédicte Lallemand; Patrick Pasau; Joël Mercier; Christian Lemaire; André Luxen; Christophe Genicot
Journal: Angew Chem Int Ed Engl Date: 2019-08-09 Impact factor: 15.336

Review 6. Imaging Techniques in Alzheimer's Disease: A Review of Applications in Early Diagnosis and Longitudinal Monitoring.

Authors: Wieke M van Oostveen; Elizabeth C M de Lange
Journal: Int J Mol Sci Date: 2021-02-20 Impact factor: 5.923

7. Human biodistribution and dosimetry of [¹¹C]-UCB-J, a PET radiotracer for imaging synaptic density.

Authors: Koen Van Laere; Michel Koole; Christopher Cawthorne; Paul Maguire; Joel Mercier; David Sciberras; Kim Serdons; Guy Bormans; Jan de Hoon
Journal: EJNMMI Phys Date: 2021-04-23

8. Exploring with [¹⁸F]UCB-H the in vivo Variations in SV2A Expression through the Kainic Acid Rat Model of Temporal Lobe Epilepsy.

Authors: Robrecht Raedt; Alain Plenevaux; Maria Elisa Serrano; Mohamed Ali Bahri; Guillaume Becker; Alain Seret; Charlotte Germonpré; Christian Lemaire; Fabrice Giacomelli; Frédéric Mievis; André Luxen; Eric Salmon; Bernard Rogister
Journal: Mol Imaging Biol Date: 2020-10 Impact factor: 3.488

9. Evaluating the In Vivo Specificity of [¹⁸F]UCB-H for the SV2A Protein, Compared with SV2B and SV2C in Rats Using microPET.

Authors: Maria Elisa Serrano; Guillaume Becker; Mohamed Ali Bahri; Alain Seret; Nathalie Mestdagh; Joël Mercier; Frédéric Mievis; Fabrice Giacomelli; Christian Lemaire; Eric Salmon; André Luxen; Alain Plenevaux
Journal: Molecules Date: 2019-05-01 Impact factor: 4.411

Review 10. Advances in CNS PET: the state-of-the-art for new imaging targets for pathophysiology and drug development.

Authors: Stuart P McCluskey; Christophe Plisson; Eugenii A Rabiner; Oliver Howes
Journal: Eur J Nucl Med Mol Imaging Date: 2019-09-21 Impact factor: 9.236