Literature DB >> 29233266

Inflammation and DNA damage: Probing pathways to cancer and neurodegeneration.

Mehran Makvandi1, Mark A Sellmyer1, Robert H Mach2.   

Abstract

Cancer and neurodegeneration represent two opposite ends of the biological spectrum but contain many common biological mechanisms. Two such mechanisms include the elevated levels of oxidative stress and DNA damage. In this brief review, we describe current approaches for imaging these biological pathways with the molecular imaging technique, Positron Emission Tomography (PET), and the potential of PET imaging studies to measure the efficacy of anticancer drugs and strategies for delaying the progression of neurodegenerative disorders.
Copyright © 2017 Elsevier Ltd. All rights reserved.

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Year:  2017        PMID: 29233266     DOI: 10.1016/j.ddtec.2017.11.001

Source DB:  PubMed          Journal:  Drug Discov Today Technol        ISSN: 1740-6749


  3 in total

1.  Examination of Diazaspiro Cores as Piperazine Bioisosteres in the Olaparib Framework Shows Reduced DNA Damage and Cytotoxicity.

Authors:  Sean W Reilly; Laura N Puentes; Khadija Wilson; Chia-Ju Hsieh; Chi-Chang Weng; Mehran Makvandi; Robert H Mach
Journal:  J Med Chem       Date:  2018-06-14       Impact factor: 7.446

Review 2.  PET Imaging of Microglial Activation-Beyond Targeting TSPO.

Authors:  Bieneke Janssen; Danielle J Vugts; Albert D Windhorst; Robert H Mach
Journal:  Molecules       Date:  2018-03-08       Impact factor: 4.411

3.  Meroterpenoids from the Brown Alga Cystoseira usneoides as Potential Anti-Inflammatory and Lung Anticancer Agents.

Authors:  Hanaa Zbakh; Eva Zubía; Carolina de Los Reyes; José M Calderón-Montaño; Miguel López-Lázaro; Virginia Motilva
Journal:  Mar Drugs       Date:  2020-04-11       Impact factor: 5.118

  3 in total

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