Baptiste Pignon1, Hugo Peyre2, Andrei Szöke1, Pierre A Geoffroy3, Benjamin Rolland4, Renaud Jardri5, Pierre Thomas5,6, Guillaume Vaiva5,6, Jean-Luc Roelandt7, Imane Benradia7, Hélène Behal8, Franck Schürhoff1, Ali Amad5,6,9. 1. 1 AP-HP, DHU PePSY, Hôpitaux universitaires Henri-Mondor, Pôle de Psychiatrie and Inserm, U955, team 15 and Fondation FondaMental and UPEC, Université Paris-Est, Faculté de médecine, Créteil, France. 2. 2 Assistance Publique-Hôpitaux de Paris, Robert Debré Hospital, Child and Adolescent Psychiatry Department and Cognitive Sciences and Psycholinguistic Laboratory, Ecole Normale Supérieure, Paris, France. 3. 3 Inserm, U1144 and Université Paris Diderot, Sorbonne Paris Cité, UMR-S 1144, and AP-HP, GH Saint-Louis-Lariboisière-F. Widal, Pôle de Psychiatrie et de Médecine Addictologique, Fondation FondaMental, Créteil, France. 4. 4 Service Universitaire d'Addictologie, Pôle UP-MOPHA, CH Le Vinatier, Univ. Lyon and CRNL Inserm U1028/CNRS UMR5292-CH Le Vinatier, Bron, France. 5. 5 Univ. Lille, CNRS UMR 9193-PsyCHIC-SCALab, & CHU Lille, Pôle de Psychiatrie, Unité CURE, Lille, France. 6. 6 Fédération régionale de recherche en santé mentale (F2RSM) Nord-Pas-de-Calais, Lille, France. 7. 7 EPSM Lille Métropole and Centre Collaborateur de l'Organisation Mondiale de la Santé pour la recherche et la formation en santé mentale and Equipe Eceve Inserm UMR 1123, Lille, France. 8. 8 Univ. Lille, CHU Lille, EA 2694 - Santé publique: épidémiologie et qualité des soins, Department of biostatistics, Lille, France. 9. 9 Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Abstract
OBJECTIVE: Individuals with psychotic symptoms may actually correspond to various subgroups, characterized by different patterns of psychotic symptoms as well as specific sociodemographic and clinical correlates. We aimed to identify groups of individuals from the general population with specific patterns of psychotic symptoms. METHODS: In a 38,694-subject survey, a latent class analysis was performed to identify subgroups based on the distribution of seven psychotic symptoms taken from the Mini International Neuropsychiatric Interview. The different classes were subsequently compared according to sociodemographic and clinical correlates. RESULTS: The best fit was obtained with a four-class solution, including the following: (1) a class with a low prevalence of all psychotic symptoms ('LOW', 85.9%); (2) a class with a high prevalence of all psychotic symptoms ('HAL + DEL', 1.7%); and classes with a high prevalence of (3) hallucinations ('HAL', 4.5%) or (4) delusions ('DEL', 7.9%). The HAL + DEL class displayed higher rates of history of trauma, social deprivation and migrant status, while the HAL and DEL classes displayed intermediate rates between HAL + DEL and LOW. HAL + DEL displayed the highest rates of psychotic and non-psychotic disorders and the use of mental health treatment, while HAL and DEL displayed intermediate rates of these disorders between HAL + DEL and LOW. In comparison to the HAL class, psychotic and substance use disorders were more frequent in the DEL class, while anxiety and mood disorders were less frequent. CONCLUSION: These findings support the hypothesis of a continuum model relating the level of psychotic symptoms to the level of global psychopathology.
OBJECTIVE: Individuals with psychotic symptoms may actually correspond to various subgroups, characterized by different patterns of psychotic symptoms as well as specific sociodemographic and clinical correlates. We aimed to identify groups of individuals from the general population with specific patterns of psychotic symptoms. METHODS: In a 38,694-subject survey, a latent class analysis was performed to identify subgroups based on the distribution of seven psychotic symptoms taken from the Mini International Neuropsychiatric Interview. The different classes were subsequently compared according to sociodemographic and clinical correlates. RESULTS: The best fit was obtained with a four-class solution, including the following: (1) a class with a low prevalence of all psychotic symptoms ('LOW', 85.9%); (2) a class with a high prevalence of all psychotic symptoms ('HAL + DEL', 1.7%); and classes with a high prevalence of (3) hallucinations ('HAL', 4.5%) or (4) delusions ('DEL', 7.9%). The HAL + DEL class displayed higher rates of history of trauma, social deprivation and migrant status, while the HAL and DEL classes displayed intermediate rates between HAL + DEL and LOW. HAL + DEL displayed the highest rates of psychotic and non-psychotic disorders and the use of mental health treatment, while HAL and DEL displayed intermediate rates of these disorders between HAL + DEL and LOW. In comparison to the HAL class, psychotic and substance use disorders were more frequent in the DEL class, while anxiety and mood disorders were less frequent. CONCLUSION: These findings support the hypothesis of a continuum model relating the level of psychotic symptoms to the level of global psychopathology.
Entities:
Keywords:
Latent class analysis; delusion; hallucinations; mental health; psychotic symptoms
Authors: Baptiste Pignon; Mohamed Lajnef; James B Kirkbride; Hugo Peyre; Aziz Ferchiou; Jean-Romain Richard; Grégoire Baudin; Sarah Tosato; Hannah Jongsma; Lieuwe de Haan; Ilaria Tarricone; Miguel Bernardo; Eva Velthorst; Mauro Braca; Celso Arango; Manuel Arrojo; Julio Bobes; Cristina Marta Del-Ben; Marta Di Forti; Charlotte Gayer-Anderson; Peter B Jones; Caterina La Cascia; Antonio Lasalvia; Paulo Rossi Menezes; Diego Quattrone; Julio Sanjuán; Jean-Paul Selten; Andrea Tortelli; Pierre-Michel Llorca; Jim van Os; Bart P F Rutten; Robin M Murray; Craig Morgan; Marion Leboyer; Andrei Szöke; Franck Schürhoff Journal: Schizophr Bull Date: 2021-10-21 Impact factor: 9.306
Authors: Rebecca McKetin; Alexandra Voce; Richard Burns; Robert Ali; Dan I Lubman; Amanda L Baker; David J Castle Journal: Front Psychiatry Date: 2018-11-19 Impact factor: 4.157
Authors: Maria Alice Brito; Ali Amad; Benjamin Rolland; Pierre A Geoffroy; Hugo Peyre; Jean-Luc Roelandt; Imane Benradia; Pierre Thomas; Guillaume Vaiva; Franck Schürhoff; Baptiste Pignon Journal: Eur Arch Psychiatry Clin Neurosci Date: 2021-02-10 Impact factor: 5.270