Sevcan A Bakkaloğlu1, Yesim Özdemir Atikel1, Fabio Paglialonga2, Constantinos J Stefanidis3, Varvara Askiti3, Enrico Vidal4, Gema Ariceta5, Engin Melek6, Enrico Verrina7, Nikoleta Printza8, Karel Vondrak9, Aleksandra Zurowska10, Ilona Zagozdzon10, Mesiha Ekim11, Elif Nursel Özmert12, Stephanie Dufek13, Augustina Jankauskiene14, Claus Peter Schmitt15, Eszter Lévai15, Johan Vande Walle16, Nur Canpolat17, Tuula Holtta18, Michel Fischbach19, Guenter Klaus20, Christoph Aufricht21, Rukshana Shroff13, Alberto Edefonti2. 1. Department of Pediatric Nephrology, Gazi University, Ankara, Turkey. 2. Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy. 3. Department of Pediatric Nephrology, A. and P. Kyriakou Children's Hospital, Athens, Greece. 4. Department of Pediatric Nephrology, Padova University, Padova, Italy. 5. Department of Pediatric Nephrology, University Hospital Vall d' Hebron, Barcelona, Spain. 6. Department of Pediatric Nephrology, Çukurova University, Adana, Turkey. 7. Dialysis Unit, Department of Pediatrics, IRCCS Giannina Gaslini, Genoa, Italy. 8. 1st Pediatric Department, Aristotle University of Thessaloniki, Thessaloníki, Greece. 9. Department of Pediatric Nephrology, University Hospital Motol, Prague, Czech Republic. 10. Department of Pediatric Nephrology, Medical University of Gdansk, Gdansk, Poland. 11. Department of Pediatric Nephrology, Ankara University, Ankara, Turkey. 12. Department of Social Pediatrics, Hacettepe University, Ankara, Turkey. 13. Department of Pediatric Nephrology, Great Ormond Street Hospital for Children, London, United Kingdom. 14. Pediatric Center, Institute of Clinical Medicine, Vilnius University, Vilnius, Lithuania. 15. Pediatric Nephrology, Center for Child and Adolescent Medicine, Heidelberg, Germany. 16. Department of Pediatric Nephrology, Utoped, Universitair Ziekenhuis Gent, Ghent, Belgium. 17. Department of Pediatric Nephrology, Cerrahpaşa Medical School, Istanbul, Turkey. 18. Department of Pediatric Nephrology, University of Helsinki, Helsinki, Finland. 19. Department of Pediatric Nephrology, Hopital de Hautepierre, Strasbourg, France. 20. Department of Pediatric Nephrology, KfH Children's Kidney Center, Marburg, Germany. 21. Department of Pediatric Nephrology, Medical University of Vienna, Vienna, Austria.
Abstract
BACKGROUND: Data on the immunization practices in pediatric chronic kidney disease (CKD) patients are scarce. The purpose of this study was to evaluate current vaccination practices for children on dialysis across European pediatric nephrology centers. METHODS: A total of 18 tertiary pediatric nephrology centers from 12 European countries were included in the study. The data on universal national immunization programs and immunization practices for children with chronic disease or risk were recorded from European Center for Disease Prevention and Control and the World Health Organization. The immunization practices and center protocols for monitoring antibody titers after vaccination in dialysis patients were obtained through a questionnaire. RESULTS: All centers included in the study recommended immunization against hepatitis B virus (HBV), diphtheria, tetanus, pertussis, Hemophilus influenzae type b (Hib), poliomyelitis, measles, mumps, rubella (MMR), and streptococcus pneumonia in dialysis patients. In 16 centers, dialysis patients were vaccinated against influenza virus annually. HBV protective antibody titers were measured in 17 centers (during dialysis period in 14 centers, during pre-renal transplantation preparations in 14 centers or in both times in 11 centers). Hepatitis A virus (HAV) was reported to be followed in 13 centers, in 8 centers during dialysis period, and in 11 centers during pre-RTx preparations. MMR and varicella-zoster virus (VZV) protective antibody titers were measured during the dialysis period or before renal transplantation (RTx) in 12 and 15 centers, respectively, and in 6 centers both titers were checked both times. CONCLUSION: There are variations in vaccination practice across Europe. Children with CKD, those undergoing dialysis, and transplant candidates should receive age-appropriate vaccinations before RTx as well as before the transition to adult nephrology clinics and antibody levels should be monitored to evaluate the immunization status before and after RTx.
BACKGROUND: Data on the immunization practices in pediatric chronic kidney disease (CKD) patients are scarce. The purpose of this study was to evaluate current vaccination practices for children on dialysis across European pediatric nephrology centers. METHODS: A total of 18 tertiary pediatric nephrology centers from 12 European countries were included in the study. The data on universal national immunization programs and immunization practices for children with chronic disease or risk were recorded from European Center for Disease Prevention and Control and the World Health Organization. The immunization practices and center protocols for monitoring antibody titers after vaccination in dialysis patients were obtained through a questionnaire. RESULTS: All centers included in the study recommended immunization against hepatitis B virus (HBV), diphtheria, tetanus, pertussis, Hemophilus influenzae type b (Hib), poliomyelitis, measles, mumps, rubella (MMR), and streptococcus pneumonia in dialysis patients. In 16 centers, dialysis patients were vaccinated against influenza virus annually. HBV protective antibody titers were measured in 17 centers (during dialysis period in 14 centers, during pre-renal transplantation preparations in 14 centers or in both times in 11 centers). Hepatitis A virus (HAV) was reported to be followed in 13 centers, in 8 centers during dialysis period, and in 11 centers during pre-RTx preparations. MMR and varicella-zoster virus (VZV) protective antibody titers were measured during the dialysis period or before renal transplantation (RTx) in 12 and 15 centers, respectively, and in 6 centers both titers were checked both times. CONCLUSION: There are variations in vaccination practice across Europe. Children with CKD, those undergoing dialysis, and transplant candidates should receive age-appropriate vaccinations before RTx as well as before the transition to adult nephrology clinics and antibody levels should be monitored to evaluate the immunization status before and after RTx.
Authors: Steven B Welch; Marc Tebruegge; Alasdair Bamford; Garth Dixon; Nigel Klein; Stephen D Marks; Nicole Ritz Journal: Pediatr Nephrol Date: 2020-11-27 Impact factor: 3.714