| Literature DB >> 29232634 |
Sadia Naureen1, Faryal Chaudhry2, Munawar Ali Munawar3, Muhammad Ashraf4, Sujhla Hamid4, Misbahul Ain Khan5.
Abstract
A series of triarylimidazoles substituted with 2-arylindoles (4a-4j) were prepared and evaluated for their in vitro α-Glucosidase inhibition. α-Glucosidase inhibition assay displayed a new class of highly potent agents The new compounds showed significant α-glucosidase inhibitory activity as compared to the standard inhibitor acrabose. Structures of synthesized compounds were determined by using Mass spectrometry FT-IR, 1H NMR and 13C NMR.Entities:
Keywords: 2-Arylindoles; Diabetes; Multicomponent reactions; NMR spectra; α-Glucosidase inhibition
Mesh：
Substances：
Year: 2017 PMID： 29232634 DOI： 10.1016/j.bioorg.2017.12.014
Source DB: PubMed Journal: Bioorg Chem ISSN： 0045-2068 Impact factor: 5.275