Carla Rognoni1, Oriana Ciani1,2, Silvia Sommariva1,3, Rosanna Tarricone1,4. 1. Centre for Research on Health and Social Care Management (CERGAS), SDA Bocconi School of Management, Bocconi University, Via Roentgen 1, 20136, Milan, Italy. 2. Evidence Synthesis & Modelling for Health Improvement (ESMI), University of Exeter Medical School, South Cloisters, St Luke's Campus, Exeter, EX1 2LU, UK. 3. Department of Community and Family Health, College of Public Health, University of South Florida, 3010 USF Banyan Circle Tampa, FL 33612, USA. 4. Department of Policy Analysis and Public Management, Bocconi University, Via Roentgen 1, 20136, Milan, Italy.
Abstract
AIM: We evaluated two treatment sequences, transarterial radioembolization followed by transarterial chemoembolization and possibly sorafenib (=TTS) versus transarterial radioembolization followed by sorafenib alone (=TS), to identify the most cost-effective pathway to treat intermediate-stage hepatocellular carcinoma from the Italian healthcare system perspective. MATERIALS & METHODS: A Markov model was developed to project costs and health outcomes for TTS and TS over a lifetime horizon. Data available at three hospitals in Italy were collected. Healthcare resource utilization was derived from standard clinical protocols. Costs were obtained from official regional tariffs. RESULTS & CONCLUSION: Taking into consideration 16 patients for TTS and 22 patients for TS pathways, the TTS sequence provided a dominant strategy in comparison to TS. Further evidence is desirable to confirm these results.
AIM: We evaluated two treatment sequences, transarterial radioembolization followed by transarterial chemoembolization and possibly sorafenib (=TTS) versus transarterial radioembolization followed by sorafenib alone (=TS), to identify the most cost-effective pathway to treat intermediate-stage hepatocellular carcinoma from the Italian healthcare system perspective. MATERIALS & METHODS: A Markov model was developed to project costs and health outcomes for TTS and TS over a lifetime horizon. Data available at three hospitals in Italy were collected. Healthcare resource utilization was derived from standard clinical protocols. Costs were obtained from official regional tariffs. RESULTS & CONCLUSION: Taking into consideration 16 patients for TTS and 22 patients for TS pathways, the TTS sequence provided a dominant strategy in comparison to TS. Further evidence is desirable to confirm these results.
Authors: J C Alonso; I Casans; F M González; D Fuster; A Rodríguez; N Sánchez; I Oyagüez; R Burgos; A O Williams; N Espinoza Journal: BMC Gastroenterol Date: 2022-07-02 Impact factor: 2.847
Authors: Sydney C Yuen; Adaeze Q Amaefule; Hannah H Kim; Breanna-Verissa Owoo; Emily F Gorman; T Joseph Mattingly Journal: Pharmacoecon Open Date: 2021-08-24