Literature DB >> 2922991

Ganglioside mapping of a human medulloblastoma xenograft.

J Gottfries1, J E Mansson, P Fredman, C J Wikstrand, H S Friedman, D D Bigner, L Svennerholm.   

Abstract

The ganglioside patterns of medulloblastomas have never been established; in this study we report the ganglioside profile of the human medulloblastoma cell line TE-671 grown as a xenograft in nude mice. Gangliosides were isolated and structurally analyzed by fast atom bombardment mass spectometry following permethylation. Identification of individual gangliosides was also performed by immunostaining of high-performance thin-layer chromatography-separated bands. Total ganglioside levels of 0.20 mumol/g of tissue were obtained, consistent with those reported for human glioma cell lines grown as xenografts; predominant monosialogangliosides of TE-671 xenografts were II3-alpha-NeuAc-LacCer (GM3) and II3-alpha-NeuAc-GgOse3Cer (GM2) but there were also relatively large proportions of IV3-alpha-NeuAc-LcOse4Cer (3'-isoLM1), IV3-alpha-NeuAc-nLcOse4Cer (3'-LM1) and a further ganglioside of the neolacto-series with an extra lactosamine moiety. The only oligosialoganglioside detected was IV3, II3-alpha-NeuAc2-GgOse4Cer (GD1a).

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Year:  1989        PMID： 2922991     DOI： 10.1007/BF00687580

Source DB:  PubMed          Journal:  Acta Neuropathol        ISSN： 0001-6322            Impact factor:   17.088


  19 in total

1.  Quantitative estimation of sialic acids. II. A colorimetric resorcinol-hydrochloric acid method.

Authors:  L SVENNERHOLM
Journal:  Biochim Biophys Acta       Date:  1957-06

2.  Sialyllactotetraosylceramide, a ganglioside marker for human malignant gliomas.

Authors:  P Fredman; H von Holst; V P Collins; L Granholm; L Svennerholm
Journal:  J Neurochem       Date:  1988-03       Impact factor: 5.372

3.  A model for human medulloblastoma. Growth, morphology, and chromosomal analysis in vitro and in athymic mice.

Authors:  H S Friedman; S H Bigner; R D McComb; S C Schold; J F Pasternak; D R Groothuis; D D Bigner
Journal:  J Neuropathol Exp Neurol       Date:  1983-09       Impact factor: 3.685

4.  Sialosyllactotetraosylceramide, a novel ganglioside antigen detected in human carcinomas by a monoclonal antibody.

Authors:  O Nilsson; J E Månsson; L Lindholm; J Holmgren; L Svennerholm
Journal:  FEBS Lett       Date:  1985-03-25       Impact factor: 4.124

5.  Characterization of new gangliosides of the lactotetraose series in murine xenografts of a human glioma cell line.

Authors:  J E Månsson; P Fredman; D D Bigner; K Molin; B Rosengren; H S Friedman; L Svennerholm
Journal:  FEBS Lett       Date:  1986-05-26       Impact factor: 4.124

6.  Phenotypic analysis of four human medulloblastoma cell lines and transplantable xenografts.

Authors:  X M He; S X Skapek; C J Wikstrand; H S Friedman; J Q Trojanowski; J T Kemshead; H B Coakham; S H Bigner; D D Bigner
Journal:  J Neuropathol Exp Neurol       Date:  1989-01       Impact factor: 3.685

7.  Chemical structure of carcinoma ganglioside antigens defined by monoclonal antibody C-50 and some allied gangliosides of human pancreatic adenocarcinoma.

Authors:  J E Månsson; P Fredman; O Nilsson; L Lindholm; J Holmgren; L Svennerholm
Journal:  Biochim Biophys Acta       Date:  1985-03-27

8.  Large alterations in ganglioside and neutral glycosphingolipid patterns in brains from cases with infantile neuronal ceroid lipofuscinosis/polyunsaturated fatty acid lipidosis.

Authors:  L Svennerholm; P Fredman; B Jungbjer; J E Månsson; B M Rynmark; K Boström; B Hagberg; L Norén; P Santavuori
Journal:  J Neurochem       Date:  1987-12       Impact factor: 5.372

9.  Structures of glycosphingolipids isolated from human embryonal carcinoma cells. The presence of mono- and disialosyl glycolipids with blood group type 1 sequence.

Authors:  M N Fukuda; B Bothner; K O Lloyd; W J Rettig; P R Tiller; A Dell
Journal:  J Biol Chem       Date:  1986-04-15       Impact factor: 5.157

Review 10.  Tumor-associated glycolipid antigens, their metabolism and organization.

Authors:  S Hakomori
Journal:  Chem Phys Lipids       Date:  1986-12-15       Impact factor: 3.329
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  1 in total

1.  Affinity-matured recombinant immunotoxin targeting gangliosides 3'-isoLM1 and 3',6'-isoLD1 on malignant gliomas.

Authors:  Hailan Piao; Chien-Tsun Kuan; Vidya Chandramohan; Stephen T Keir; Charles N Pegram; Xuhui Bao; Jan-Eric Månsson; Ira H Pastan; Darell D Bigner
Journal:  MAbs       Date:  2013-07-25       Impact factor: 5.857
  1 in total

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