L Tuchtan1, E Lesieur2, C Bartoli3, C Delteil4, L Sarda-Quarello5, J Torrents6, S Sigaudy7, M-D Piercecchi8, G Gorincour9. 1. Department of forensic pathology, CHU Timone, AP-HM, 264, rue Saint-Pierre, 13385 Marseille cedex 5, France; CNRS, EFS, ADES UMR 7268, Aix-Marseille university, 13916 Marseille, France; Department of fetopathology, CHU Timone, AP-HM, 264, rue Saint-Pierre, 13385 Marseille cedex 5, France. Electronic address: lucile.tuchtan@ap-hm.fr. 2. Center for prenatal diagnosis, children hospital, CHU Timone, AP-HM, 264, rue Saint-Pierre, 13385 Marseille cedex 5, France. Electronic address: emmanuelle.lesieur@ap-hm.fr. 3. Department of forensic pathology, CHU Timone, AP-HM, 264, rue Saint-Pierre, 13385 Marseille cedex 5, France; CNRS, EFS, ADES UMR 7268, Aix-Marseille university, 13916 Marseille, France. Electronic address: Christophe.bartoli@ap-hm.fr. 4. Department of forensic pathology, CHU Timone, AP-HM, 264, rue Saint-Pierre, 13385 Marseille cedex 5, France; CNRS, EFS, ADES UMR 7268, Aix-Marseille university, 13916 Marseille, France. Electronic address: clemence.delteil@ap-hm.fr. 5. Department of fetopathology, CHU Timone, AP-HM, 264, rue Saint-Pierre, 13385 Marseille cedex 5, France. Electronic address: laure.sarda@ap-hm.fr. 6. Department of forensic pathology, CHU Timone, AP-HM, 264, rue Saint-Pierre, 13385 Marseille cedex 5, France; Department of fetopathology, CHU Timone, AP-HM, 264, rue Saint-Pierre, 13385 Marseille cedex 5, France. Electronic address: julia.torrents@ap-hm.fr. 7. Center for prenatal diagnosis, children hospital, CHU Timone, AP-HM, 264, rue Saint-Pierre, 13385 Marseille cedex 5, France. Electronic address: sabine.sigaudy@ap-hm.fr. 8. Department of forensic pathology, CHU Timone, AP-HM, 264, rue Saint-Pierre, 13385 Marseille cedex 5, France; CNRS, EFS, ADES UMR 7268, Aix-Marseille university, 13916 Marseille, France. Electronic address: Marie-dominique.PIERCECCHI@ap-hm.fr. 9. Center for prenatal diagnosis, children hospital, CHU Timone, AP-HM, 264, rue Saint-Pierre, 13385 Marseille cedex 5, France; Department of pediatric and prenatal imaging, La-Timone children hospital, Aix-Marseille university, CHU Timone, 264, rue Saint-Pierre, 13385 Marseille cedex 5, France. Electronic address: Guillaume.gorincour@ap-hm.fr.
Abstract
PURPOSE: To determine the sensitivity and specificity of post-mortem ultrasound in the diagnosis of major congenital abnormalities of fetuses using conventional autopsy as the standard of reference. MATERIAL AND METHODS: All fetuses coming from terminations of pregnancy or intrauterine fetal deaths in a single institution were included. A total of 75 fetuses were included during the study period. The results of post-mortem ultrasound examinations were compared to those of conventional autopsy that served as standard of reference. RESULTS: Gestational age of the fetuses ranged from 15 to 38 weeks gestation. A complete post-mortem ultrasound assessment was possible in all fetuses. Regarding detection of brain abnormalities, post-mortem ultrasound had a sensitivity of 81.5% or 4/5 (95% CI: 63.3-91.8%), and a specificity of 97.9% (95% CI: 89.1-99.6%). Specificities for the diagnosis of thoracic, cardiac, urinary tract, spinal and bone abnormalities were 100%. CONCLUSION: Post-mortem ultrasound shows high sensitivity and specificity for the diagnosis of congenital structural abnormalities as compared to conventional autopsy, with the exception of congenital cardiac diseases.
PURPOSE: To determine the sensitivity and specificity of post-mortem ultrasound in the diagnosis of major congenital abnormalities of fetuses using conventional autopsy as the standard of reference. MATERIAL AND METHODS: All fetuses coming from terminations of pregnancy or intrauterine fetal deaths in a single institution were included. A total of 75 fetuses were included during the study period. The results of post-mortem ultrasound examinations were compared to those of conventional autopsy that served as standard of reference. RESULTS: Gestational age of the fetuses ranged from 15 to 38 weeks gestation. A complete post-mortem ultrasound assessment was possible in all fetuses. Regarding detection of brain abnormalities, post-mortem ultrasound had a sensitivity of 81.5% or 4/5 (95% CI: 63.3-91.8%), and a specificity of 97.9% (95% CI: 89.1-99.6%). Specificities for the diagnosis of thoracic, cardiac, urinary tract, spinal and bone abnormalities were 100%. CONCLUSION: Post-mortem ultrasound shows high sensitivity and specificity for the diagnosis of congenital structural abnormalities as compared to conventional autopsy, with the exception of congenital cardiac diseases.
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