Abhinav Ajaykumar1,2, Hugo Soudeyns3,4, Fatima Kakkar5, Jason Brophy6, Ari Bitnun7, Ariane Alimenti8,9, Arianne Y K Albert9,10, Deborah M Money11,9,10, Hélène C F Côté1,2,10. 1. Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada. 2. Centre for Blood Research, University of British Columbia, Vancouver, Canada. 3. Unité d'immunopathologie virale, Centre de Recherche du CHU Sainte-Justine, Montreal, Canada. 4. Department of Microbiology, Infectiology and Immunology, Faculty of Medicine, Université de Montréal, Montreal, Canada. 5. Department of Pediatrics, CHU Sainte-Justine, Université de Montréal, Montreal, Canada. 6. Department of Pediatrics, Children's Hospital of Eastern Ontario, University of Ottawa, Ottawa, Canada. 7. Department of Pediatrics, Hospital for Sick Children, University of Toronto, Toronto, Canada. 8. Department of Pediatrics, University of British Columbia, Vancouver, Canada. 9. BC Women's Hospital and Health Centre, Vancouver, Canada. 10. Women's Health Research Institute, Vancouver, Canada. 11. Department of Obstetrics and Gynecology, University of British Columbia, Vancouver, Canada.
Abstract
Background: Maternal combination antiretroviral therapy (cART) during pregnancy could impact the health of human immunodeficiency virus (HIV)-exposed, HIV-uninfected (HEU) children, because some antiretrovirals cross the placenta and can inhibit telomerase. Our objective was to compare leukocyte telomere length (LTL) in HEU children and HIV-unexposed, HIV-uninfected (HUU) children at birth and in early life and to investigate any relationship with cART exposure. Methods: HEU and HUU children's blood LTL was compared cross-sectionally at birth, and during the first three years of life. Longitudinal HEU LTL dynamics was evaluated over that same period. Results: At birth, the LTL in HEU children (n = 114) was not shorter than that in HUU children (n = 86), but female infants had longer LTL than male infants. Maternal cART (duration or type) showed no association with shorter infant LTL. Among 214 HEU children age- and sex-matched at a 1:1 ratio to HUU children, LTL declined similarly in both groups. In a longitudinal analysis, LTL attrition in HEU children was rapid from birth to 1 year of age and gradual thereafter. Zidovudine prophylaxis did not significantly alter LTL. Conclusions: Our results indicate that from birth to 3 years of age, the LTL in HEU children is not negatively affected by exposure to maternal HIV infection and cART, at least not to the regimens used within this Canadian cohort, a reassuring finding.
Background: Maternal combination antiretroviral therapy (cART) during pregnancy could impact the health of human immunodeficiency virus (HIV)-exposed, HIV-uninfected (HEU) children, because some antiretrovirals cross the placenta and can inhibit telomerase. Our objective was to compare leukocyte telomere length (LTL) in HEU children and HIV-unexposed, HIV-uninfected (HUU) children at birth and in early life and to investigate any relationship with cART exposure. Methods: HEU and HUU children's blood LTL was compared cross-sectionally at birth, and during the first three years of life. Longitudinal HEU LTL dynamics was evaluated over that same period. Results: At birth, the LTL in HEU children (n = 114) was not shorter than that in HUU children (n = 86), but female infants had longer LTL than male infants. Maternal cART (duration or type) showed no association with shorter infantLTL. Among 214 HEU children age- and sex-matched at a 1:1 ratio to HUU children, LTL declined similarly in both groups. In a longitudinal analysis, LTL attrition in HEU children was rapid from birth to 1 year of age and gradual thereafter. Zidovudine prophylaxis did not significantly alter LTL. Conclusions: Our results indicate that from birth to 3 years of age, the LTL in HEU children is not negatively affected by exposure to maternal HIV infection and cART, at least not to the regimens used within this Canadian cohort, a reassuring finding.
Authors: John C Forbes; Ariane M Alimenti; Joel Singer; Jason C Brophy; Ari Bitnun; Lindy M Samson; Deborah M Money; Terry C K Lee; Normand D Lapointe; Stanley E Read Journal: AIDS Date: 2012-03-27 Impact factor: 4.177
Authors: Hélène C F Côté; Janet Raboud; Ari Bitnun; Ariane Alimenti; Deborah M Money; Evelyn Maan; Adriana Costei; Izabelle Gadawski; Christina Diong; Stanley Read; Sandy Shen; P Richard Harrigan; David R Burdge; Susan M King; John C Forbes Journal: J Infect Dis Date: 2008-09-15 Impact factor: 5.226
Authors: Philip C Haycock; Stephen Burgess; Aayah Nounu; Jie Zheng; George N Okoli; Jack Bowden; Kaitlin Hazel Wade; Nicholas J Timpson; David M Evans; Peter Willeit; Abraham Aviv; Tom R Gaunt; Gibran Hemani; Massimo Mangino; Hayley Patricia Ellis; Kathreena M Kurian; Karen A Pooley; Rosalind A Eeles; Jeffrey E Lee; Shenying Fang; Wei V Chen; Matthew H Law; Lisa M Bowdler; Mark M Iles; Qiong Yang; Bradford B Worrall; Hugh Stephen Markus; Rayjean J Hung; Chris I Amos; Amanda B Spurdle; Deborah J Thompson; Tracy A O'Mara; Brian Wolpin; Laufey Amundadottir; Rachael Stolzenberg-Solomon; Antonia Trichopoulou; N Charlotte Onland-Moret; Eiliv Lund; Eric J Duell; Federico Canzian; Gianluca Severi; Kim Overvad; Marc J Gunter; Rosario Tumino; Ulrika Svenson; Andre van Rij; Annette F Baas; Matthew J Bown; Nilesh J Samani; Femke N G van t'Hof; Gerard Tromp; Gregory T Jones; Helena Kuivaniemi; James R Elmore; Mattias Johansson; James Mckay; Ghislaine Scelo; Robert Carreras-Torres; Valerie Gaborieau; Paul Brennan; Paige M Bracci; Rachel E Neale; Sara H Olson; Steven Gallinger; Donghui Li; Gloria M Petersen; Harvey A Risch; Alison P Klein; Jiali Han; Christian C Abnet; Neal D Freedman; Philip R Taylor; John M Maris; Katja K Aben; Lambertus A Kiemeney; Sita H Vermeulen; John K Wiencke; Kyle M Walsh; Margaret Wrensch; Terri Rice; Clare Turnbull; Kevin Litchfield; Lavinia Paternoster; Marie Standl; Gonçalo R Abecasis; John Paul SanGiovanni; Yong Li; Vladan Mijatovic; Yadav Sapkota; Siew-Kee Low; Krina T Zondervan; Grant W Montgomery; Dale R Nyholt; David A van Heel; Karen Hunt; Dan E Arking; Foram N Ashar; Nona Sotoodehnia; Daniel Woo; Jonathan Rosand; Mary E Comeau; W Mark Brown; Edwin K Silverman; John E Hokanson; Michael H Cho; Jennie Hui; Manuel A Ferreira; Philip J Thompson; Alanna C Morrison; Janine F Felix; Nicholas L Smith; Angela M Christiano; Lynn Petukhova; Regina C Betz; Xing Fan; Xuejun Zhang; Caihong Zhu; Carl D Langefeld; Susan D Thompson; Feijie Wang; Xu Lin; David A Schwartz; Tasha Fingerlin; Jerome I Rotter; Mary Frances Cotch; Richard A Jensen; Matthias Munz; Henrik Dommisch; Arne S Schaefer; Fang Han; Hanna M Ollila; Ryan P Hillary; Omar Albagha; Stuart H Ralston; Chenjie Zeng; Wei Zheng; Xiao-Ou Shu; Andre Reis; Steffen Uebe; Ulrike Hüffmeier; Yoshiya Kawamura; Takeshi Otowa; Tsukasa Sasaki; Martin Lloyd Hibberd; Sonia Davila; Gang Xie; Katherine Siminovitch; Jin-Xin Bei; Yi-Xin Zeng; Asta Försti; Bowang Chen; Stefano Landi; Andre Franke; Annegret Fischer; David Ellinghaus; Carlos Flores; Imre Noth; Shwu-Fan Ma; Jia Nee Foo; Jianjun Liu; Jong-Won Kim; David G Cox; Olivier Delattre; Olivier Mirabeau; Christine F Skibola; Clara S Tang; Merce Garcia-Barcelo; Kai-Ping Chang; Wen-Hui Su; Yu-Sun Chang; Nicholas G Martin; Scott Gordon; Tracey D Wade; Chaeyoung Lee; Michiaki Kubo; Pei-Chieng Cha; Yusuke Nakamura; Daniel Levy; Masayuki Kimura; Shih-Jen Hwang; Steven Hunt; Tim Spector; Nicole Soranzo; Ani W Manichaikul; R Graham Barr; Bratati Kahali; Elizabeth Speliotes; Laura M Yerges-Armstrong; Ching-Yu Cheng; Jost B Jonas; Tien Yin Wong; Isabella Fogh; Kuang Lin; John F Powell; Kenneth Rice; Caroline L Relton; Richard M Martin; George Davey Smith Journal: JAMA Oncol Date: 2017-05-01 Impact factor: 31.777
Authors: Hélène C F Côté; Hugo Soudeyns; Anona Thorne; Ariane Alimenti; Valérie Lamarre; Evelyn J Maan; Beheroze Sattha; Joel Singer; Normand Lapointe; Deborah M Money; John Forbes; Judy Wong; Ari Bitnun; Lindy Samson; Jason Brophy; David Burdge; Neora Pick; Julie van Schalkwyk; Julio Montaner; Marianne Harris; Patti Janssen Journal: PLoS One Date: 2012-07-16 Impact factor: 3.240
Authors: Giovanni Almanzar; Gernot Eberle; Andrea Lassacher; Christian Specht; Christian Koppelstaetter; Peter Heinz-Erian; Rudolf Trawöger; David Bernhard; Martina Prelog Journal: BMC Pediatr Date: 2013-04-18 Impact factor: 2.125
Authors: Abhinav Ajaykumar; Mayanne Zhu; Fatima Kakkar; Jason Brophy; Ari Bitnun; Ariane Alimenti; Hugo Soudeyns; Sara Saberi; Arianne Y K Albert; Deborah M Money; Hélène C F Côté Journal: J Infect Dis Date: 2021-02-24 Impact factor: 5.226
Authors: Youjin Wang; Sean S Brummel; Erin Beilstein-Wedel; Casey L Dagnall; Rohan Hazra; Deborah Kacanek; Ellen G Chadwick; Carmen J Marsit; Stephen J Chanock; Sharon A Savage; Miriam C Poirier; Mitchell J Machiela; Eric A Engels Journal: AIDS Date: 2019-11-01 Impact factor: 4.177
Authors: Annalisa Dalzini; Maria Raffaella Petrara; Giovanni Ballin; Marisa Zanchetta; Carlo Giaquinto; Anita De Rossi Journal: J Immunol Res Date: 2020-05-16 Impact factor: 4.818