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Literature DB >> 29225548

Modulation of Abnormal Sodium Channel Currents in Heart and Brain: Hope for SUDEP Prevention and Seizure Reduction.

Lindsey B Gano, Heidi L Grabenstatter.

Abstract

Entities: Disease

Year: 2017 PMID： 29225548 PMCID： PMC5716504 DOI： 10.5698/1535-7597.17.5.306

Source DB: PubMed Journal: Epilepsy Curr ISSN： 1535-7511 Impact factor: 7.500

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24 in total

1. Sodium channel Scn1b null mice exhibit prolonged QT and RR intervals.

Authors: Luis F Lopez-Santiago; Laurence S Meadows; Sara J Ernst; Chunling Chen; Jyoti Dhar Malhotra; Dyke P McEwen; Audrey Speelman; Jeffrey L Noebels; Sebastian K G Maier; Anatoli N Lopatin; Lori L Isom
Journal: J Mol Cell Cardiol Date: 2007-08-10 Impact factor: 5.000

2. Prolongation of action potential duration and QT interval during epilepsy linked to increased contribution of neuronal sodium channels to cardiac late Na+ current: potential mechanism for sudden death in epilepsy.

Authors: Michael Biet; Nathalie Morin; Melissa Lessard-Beaudoin; Rona K Graham; Sandra Duss; Jonathan Gagné; Nathalie T Sanon; Lionel Carmant; Robert Dumaine
Journal: Circ Arrhythm Electrophysiol Date: 2015-06-11

3. Incidence and mechanisms of cardiorespiratory arrests in epilepsy monitoring units (MORTEMUS): a retrospective study.

Authors: Philippe Ryvlin; Lina Nashef; Samden D Lhatoo; Lisa M Bateman; Jonathan Bird; Andrew Bleasel; Paul Boon; Arielle Crespel; Barbara A Dworetzky; Hans Høgenhaven; Holger Lerche; Louis Maillard; Michael P Malter; Cecile Marchal; Jagarlapudi M K Murthy; Michael Nitsche; Ekaterina Pataraia; Terje Rabben; Sylvain Rheims; Bernard Sadzot; Andreas Schulze-Bonhage; Masud Seyal; Elson L So; Mark Spitz; Anna Szucs; Meng Tan; James X Tao; Torbjörn Tomson
Journal: Lancet Neurol Date: 2013-09-04 Impact factor: 44.182

4. Scn1b deletion leads to increased tetrodotoxin-sensitive sodium current, altered intracellular calcium homeostasis and arrhythmias in murine hearts.

Authors: Xianming Lin; Heather O'Malley; Chunling Chen; David Auerbach; Monique Foster; Akshay Shekhar; Mingliang Zhang; William Coetzee; José Jalife; Glenn I Fishman; Lori Isom; Mario Delmar
Journal: J Physiol Date: 2014-09-17 Impact factor: 5.182

Modulation of Abnormal Sodium Channel Currents in Heart and Brain: Hope for SUDEP Prevention and Seizure Reduction.

1. Sodium channel Scn1b null mice exhibit prolonged QT and RR intervals.

2. Prolongation of action potential duration and QT interval during epilepsy linked to increased contribution of neuronal sodium channels to cardiac late Na+ current: potential mechanism for sudden death in epilepsy.

3. Incidence and mechanisms of cardiorespiratory arrests in epilepsy monitoring units (MORTEMUS): a retrospective study.

4. Scn1b deletion leads to increased tetrodotoxin-sensitive sodium current, altered intracellular calcium homeostasis and arrhythmias in murine hearts.

5. Sudden unexpected death in a mouse model of Dravet syndrome.

6. Sudden unexpected death in epilepsy genetics: Molecular diagnostics and prevention.

7. Severe epilepsy resulting from genetic interaction between Scn2a and Kcnq2.

Review 8. Genomic biomarkers of SUDEP in brain and heart.

9. Pathogenic mechanism of recurrent mutations of SCN8A in epileptic encephalopathy.

10. Unexpected Efficacy of a Novel Sodium Channel Modulator in Dravet Syndrome.