Literature DB >> 29225529

The Big Picture: Systems Biology Approach to Antiepileptic Drug Discovery.

Jennifer A Kearney.   

Abstract

Entities:  

Year:  2017        PMID: 29225529      PMCID: PMC5716118          DOI: 10.5698/1535-7597.17.4.232

Source DB:  PubMed          Journal:  Epilepsy Curr        ISSN: 1535-7511            Impact factor:   7.500


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  11 in total

1.  The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease.

Authors:  Justin Lamb; Emily D Crawford; David Peck; Joshua W Modell; Irene C Blat; Matthew J Wrobel; Jim Lerner; Jean-Philippe Brunet; Aravind Subramanian; Kenneth N Ross; Michael Reich; Haley Hieronymus; Guo Wei; Scott A Armstrong; Stephen J Haggarty; Paul A Clemons; Ru Wei; Steven A Carr; Eric S Lander; Todd R Golub
Journal:  Science       Date:  2006-09-29       Impact factor: 47.728

2.  High throughput screening for inhibitors of REST in neural derivatives of human embryonic stem cells reveals a chemical compound that promotes expression of neuronal genes.

Authors:  Jérémie Charbord; Pauline Poydenot; Caroline Bonnefond; Maxime Feyeux; Fabrice Casagrande; Benjamin Brinon; Laetitia Francelle; Gwenaelle Aurégan; Martine Guillermier; Michel Cailleret; Pedro Viegas; Camille Nicoleau; Cécile Martinat; Emmanuel Brouillet; Elena Cattaneo; Marc Peschanski; Marc Lechuga; Anselme L Perrier
Journal:  Stem Cells       Date:  2013-09       Impact factor: 6.277

3.  Effect of Withania somnifera Dunal root extract against pentylenetetrazol seizure threshold in mice: possible involvement of GABAergic system.

Authors:  S K Kulkarni; Kiran Kumar Akula; Ashish Dhir
Journal:  Indian J Exp Biol       Date:  2008-06       Impact factor: 0.818

Review 4.  Brain REST/NRSF Is Not Only a Silent Repressor but Also an Active Protector.

Authors:  Yangang Zhao; Min Zhu; Yanlan Yu; Linli Qiu; Yuanyuan Zhang; Li He; Jiqiang Zhang
Journal:  Mol Neurobiol       Date:  2016-01-07       Impact factor: 5.590

5.  Lean Big Data integration in systems biology and systems pharmacology.

Authors:  Avi Ma'ayan; Andrew D Rouillard; Neil R Clark; Zichen Wang; Qiaonan Duan; Yan Kou
Journal:  Trends Pharmacol Sci       Date:  2014-08-07       Impact factor: 14.819

6.  Systems genetics identifies Sestrin 3 as a regulator of a proconvulsant gene network in human epileptic hippocampus.

Authors:  Jacques Behmoaras; Leonardo Bottolo; Michelle L Krishnan; Katharina Pernhorst; Paola L Meza Santoscoy; Michael R Johnson; Tiziana Rossetti; Doug Speed; Prashant K Srivastava; Marc Chadeau-Hyam; Nabil Hajji; Aleksandra Dabrowska; Maxime Rotival; Banafsheh Razzaghi; Stjepana Kovac; Klaus Wanisch; Federico W Grillo; Anna Slaviero; Sarah R Langley; Kirill Shkura; Paolo Roncon; Tisham De; Manuel Mattheisen; Pitt Niehusmann; Terence J O'Brien; Slave Petrovski; Marec von Lehe; Per Hoffmann; Johan Eriksson; Alison J Coffey; Sven Cichon; Matthew Walker; Michele Simonato; Bénédicte Danis; Manuela Mazzuferi; Patrik Foerch; Susanne Schoch; Vincenzo De Paola; Rafal M Kaminski; Vincent T Cunliffe; Albert J Becker; Enrico Petretto
Journal:  Nat Commun       Date:  2015-01-23       Impact factor: 14.919

7.  Genetic variability in the regulation of gene expression in ten regions of the human brain.

Authors:  Adaikalavan Ramasamy; Daniah Trabzuni; Sebastian Guelfi; Vibin Varghese; Colin Smith; Robert Walker; Tisham De; Lachlan Coin; Rohan de Silva; Mark R Cookson; Andrew B Singleton; John Hardy; Mina Ryten; Michael E Weale
Journal:  Nat Neurosci       Date:  2014-08-31       Impact factor: 24.884

8.  Genetic determinants of common epilepsies: a meta-analysis of genome-wide association studies.

Authors: 
Journal:  Lancet Neurol       Date:  2014-07-30       Impact factor: 44.182

9.  Transcriptional landscape of the prenatal human brain.

Authors:  Jeremy A Miller; Song-Lin Ding; Susan M Sunkin; Kimberly A Smith; Lydia Ng; Aaron Szafer; Amanda Ebbert; Zackery L Riley; Joshua J Royall; Kaylynn Aiona; James M Arnold; Crissa Bennet; Darren Bertagnolli; Krissy Brouner; Stephanie Butler; Shiella Caldejon; Anita Carey; Christine Cuhaciyan; Rachel A Dalley; Nick Dee; Tim A Dolbeare; Benjamin A C Facer; David Feng; Tim P Fliss; Garrett Gee; Jeff Goldy; Lindsey Gourley; Benjamin W Gregor; Guangyu Gu; Robert E Howard; Jayson M Jochim; Chihchau L Kuan; Christopher Lau; Chang-Kyu Lee; Felix Lee; Tracy A Lemon; Phil Lesnar; Bergen McMurray; Naveed Mastan; Nerick Mosqueda; Theresa Naluai-Cecchini; Nhan-Kiet Ngo; Julie Nyhus; Aaron Oldre; Eric Olson; Jody Parente; Patrick D Parker; Sheana E Parry; Allison Stevens; Mihovil Pletikos; Melissa Reding; Kate Roll; David Sandman; Melaine Sarreal; Sheila Shapouri; Nadiya V Shapovalova; Elaine H Shen; Nathan Sjoquist; Clifford R Slaughterbeck; Michael Smith; Andy J Sodt; Derric Williams; Lilla Zöllei; Bruce Fischl; Mark B Gerstein; Daniel H Geschwind; Ian A Glass; Michael J Hawrylycz; Robert F Hevner; Hao Huang; Allan R Jones; James A Knowles; Pat Levitt; John W Phillips; Nenad Sestan; Paul Wohnoutka; Chinh Dang; Amy Bernard; John G Hohmann; Ed S Lein
Journal:  Nature       Date:  2014-04-02       Impact factor: 49.962

10.  Rare and common epilepsies converge on a shared gene regulatory network providing opportunities for novel antiepileptic drug discovery.

Authors:  Andree Delahaye-Duriez; Prashant Srivastava; Kirill Shkura; Sarah R Langley; Liisi Laaniste; Aida Moreno-Moral; Bénédicte Danis; Manuela Mazzuferi; Patrik Foerch; Elena V Gazina; Kay Richards; Steven Petrou; Rafal M Kaminski; Enrico Petretto; Michael R Johnson
Journal:  Genome Biol       Date:  2016-12-13       Impact factor: 13.583

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