AIMS: Omentin-1 was proved to be associated with ischemic stroke clinical functional outcome. It also predicted carotid atherosclerosis among metabolic syndrome subjects and type 2 diabetes patients. Our aim was to examine the association of omentin-1 levels with carotid plaque instability and stenosis degree among ischemic stroke patients. METHODS: A total of 173 acute ischemic stroke patients were included in this study. Serum omentin-1 levels were assayed. Carotid ultrasound examinations were performed to evaluate the carotid plaque instability and stenosis degree. Multivariable logistic analyses were used to examine the association of serum omentin-1 levels with carotid plaque instability and stenosis degree. RESULTS: Ischemic stroke patients with unstable carotid plaque had significantly lower levels of serum omentin-1 than patients with stable plaque (53 [40.2-64.1] vs 61.8 [52.4-77.2] ng/ml, P＜0.01). Subjects in the highest tertile of serum omentin-1 levels had a 0.31-fold risk of having unstable plaque compared with those in the lowest tertile (P＜0.05), and its trend test was significant (P for trend=0.03). The integrated discrimination improvement was significantly improved in predicting carotid plaque instability when omentin-1 data was added to the multivariable logistic regression model. No significant association was detected between omentin-1 and moderate-severe carotid stenosis or occlusion. CONCLUSIONS: Among ischemic stroke patients, higher omentin-1 levels were inversely associated with carotid plaque instability, but not associated with moderate-severe carotid stenosis or occlusion. Omentin-1 may represent a biomarker for predicting carotid plaque instability of acute ischemic stroke patients.
AIMS: Omentin-1 was proved to be associated with ischemic stroke clinical functional outcome. It also predicted carotid atherosclerosis among metabolic syndrome subjects and type 2 diabetespatients. Our aim was to examine the association of omentin-1 levels with carotid plaque instability and stenosis degree among ischemic strokepatients. METHODS: A total of 173 acute ischemic strokepatients were included in this study. Serum omentin-1 levels were assayed. Carotid ultrasound examinations were performed to evaluate the carotid plaque instability and stenosis degree. Multivariable logistic analyses were used to examine the association of serum omentin-1 levels with carotid plaque instability and stenosis degree. RESULTS:Ischemic strokepatients with unstable carotid plaque had significantly lower levels of serum omentin-1 than patients with stable plaque (53 [40.2-64.1] vs 61.8 [52.4-77.2] ng/ml, P＜0.01). Subjects in the highest tertile of serum omentin-1 levels had a 0.31-fold risk of having unstable plaque compared with those in the lowest tertile (P＜0.05), and its trend test was significant (P for trend=0.03). The integrated discrimination improvement was significantly improved in predicting carotid plaque instability when omentin-1 data was added to the multivariable logistic regression model. No significant association was detected between omentin-1 and moderate-severe carotid stenosis or occlusion. CONCLUSIONS: Among ischemic strokepatients, higher omentin-1 levels were inversely associated with carotid plaque instability, but not associated with moderate-severe carotid stenosis or occlusion. Omentin-1 may represent a biomarker for predicting carotid plaque instability of acute ischemic strokepatients.
Authors: Shyam Prabhakaran; Tatjana Rundek; Romel Ramas; Mitchell S V Elkind; Myunghee Cho Paik; Bernadette Boden-Albala; Ralph L Sacco Journal: Stroke Date: 2006-09-28 Impact factor: 7.914
Authors: Rong-Ze Yang; Mi-Jeong Lee; Hong Hu; Jessica Pray; Hai-Bin Wu; Barbara C Hansen; Alan R Shuldiner; Susan K Fried; John C McLenithan; Da-Wei Gong Journal: Am J Physiol Endocrinol Metab Date: 2006-03-10 Impact factor: 4.310