Literature DB >> 29225067

The dynamics of native Atoh7 protein expression during mouse retinal histogenesis, revealed with a new antibody.

Joel B Miesfeld1, Tom Glaser1, Nadean L Brown2.   

Abstract

The Atoh7 transcription factor catalyzes the rate-limiting step in the specification of retinal ganglion cells (RGCs). As a tool to study vertebrate retinal development, we validate an antibody that recognizes human and mouse Atoh7 polypeptide, using informative knockout and transgenic mouse tissues and overexpression experiments. The transient features of Atoh7 protein expression during retinal neurogenesis match the expected pattern at the tissue and cellular level. Further, we compare endogenous Atoh7 to established RGC markers, reporter mouse lines and cell cycle markers, demonstrating the utility of the antibody to investigate molecular mechanisms of retinal histogenesis.
Copyright © 2017 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Atoh7; Math5; Neurogenesis; Optic nerve; Retina; Retinal ganglion cell; bHLH factor

Mesh：

Substances：

Year:  2017        PMID： 29225067      PMCID： PMC5835195          DOI： 10.1016/j.gep.2017.11.006

Source DB:  PubMed          Journal:  Gene Expr Patterns        ISSN： 1567-133X            Impact factor:   1.224


  34 in total

1.  Math5 defines the ganglion cell competence state in a subpopulation of retinal progenitor cells exiting the cell cycle.

Authors:  Joseph A Brzezinski; Lev Prasov; Tom Glaser
Journal:  Dev Biol       Date:  2012-03-15       Impact factor: 3.582

2.  Pushing the envelope of retinal ganglion cell genesis: context dependent function of Math5 (Atoh7).

Authors:  Lev Prasov; Tom Glaser
Journal:  Dev Biol       Date:  2012-05-15       Impact factor: 3.582

3.  A gene network downstream of transcription factor Math5 regulates retinal progenitor cell competence and ganglion cell fate.

Authors:  Xiuqian Mu; Xueyao Fu; Hongxia Sun; Phillip D Beremand; Terry L Thomas; William H Klein
Journal:  Dev Biol       Date:  2005-04-15       Impact factor: 3.582

4.  Math5 is required for both early retinal neuron differentiation and cell cycle progression.

Authors:  Tien T Le; Emily Wroblewski; Sima Patel; Amy N Riesenberg; Nadean L Brown
Journal:  Dev Biol       Date:  2006-04-07       Impact factor: 3.582

5.  Epitope-tagging Math5 and Pou4f2: new tools to study retinal ganglion cell development in the mouse.

Authors:  Xueyao Fu; Takae Kiyama; Renzhong Li; Mark Russell; William H Klein; Xiuqian Mu
Journal:  Dev Dyn       Date:  2009-09       Impact factor: 3.780

6.  Interkinetic nuclear migration and the selection of neurogenic cell divisions during vertebrate retinogenesis.

Authors:  Lisa M Baye; Brian A Link
Journal:  J Neurosci       Date:  2007-09-19       Impact factor: 6.167

7.  Math5 expression and function in the central auditory system.

Authors:  Sara M Saul; Joseph A Brzezinski; Richard A Altschuler; Susan E Shore; Dellaney D Rudolph; Lisa L Kabara; Karin E Halsey; Robert B Hufnagel; Jianxun Zhou; David F Dolan; Tom Glaser
Journal:  Mol Cell Neurosci       Date:  2007-09-20       Impact factor: 4.314

8.  Deletion of a remote enhancer near ATOH7 disrupts retinal neurogenesis, causing NCRNA disease.

Authors:  Noor M Ghiasvand; Dellaney D Rudolph; Mohammad Mashayekhi; Joseph A Brzezinski; Daniel Goldman; Tom Glaser
Journal:  Nat Neurosci       Date:  2011-03-27       Impact factor: 24.884

9.  bHLH proteins involved in Drosophila neurogenesis are mutually regulated at the level of stability.

Authors:  Marianthi Kiparaki; Ioanna Zarifi; Christos Delidakis
Journal:  Nucleic Acids Res       Date:  2015-02-18       Impact factor: 16.971

10.  Evolutionary changes in transcription factor coding sequence quantitatively alter sensory organ development and function.

Authors:  Simon Weinberger; Matthew P Topping; Jiekun Yan; Annelies Claeys; Natalie De Geest; Duru Ozbay; Talah Hassan; Xiaoli He; Joerg T Albert; Bassem A Hassan; Ariane Ramaekers
Journal:  Elife       Date:  2017-04-13       Impact factor: 8.140
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  13 in total

1.  Simultaneous Requirements for Hes1 in Retinal Neurogenesis and Optic Cup-Stalk Boundary Maintenance.

Authors:  Bernadett Bosze; Myung-Soon Moon; Ryoichiro Kageyama; Nadean L Brown
Journal:  J Neurosci       Date:  2020-01-16       Impact factor: 6.167

2.  Transcriptome Changes in Retinal Pigment Epithelium Post-PNU-282987 Treatment Associated with Adult Retinal Neurogenesis in Mice.

Authors:  Sarah E Webster; Jake B Spitsbergen; David M Linn; Mark K Webster; Deborah Otteson; Cynthia Cooley-Themm; Cindy L Linn
Journal:  J Mol Neurosci       Date:  2022-07-22       Impact factor: 2.866

3.  Integral bHLH factor regulation of cell cycle exit and RGC differentiation.

Authors:  Kate A Maurer; Angelica Kowalchuk; Farnaz Shoja-Taheri; Nadean L Brown
Journal:  Dev Dyn       Date:  2018-06-26       Impact factor: 3.780

4.  Single Cell Transcriptomic Analyses Reveal the Impact of bHLH Factors on Human Retinal Organoid Development.

Authors:  Xiangmei Zhang; Igor Mandric; Kevin H Nguyen; Thao T T Nguyen; Matteo Pellegrini; James C R Grove; Steven Barnes; Xian-Jie Yang
Journal:  Front Cell Dev Biol       Date:  2021-05-13

5.  Rbpj direct regulation of Atoh7 transcription in the embryonic mouse retina.

Authors:  Joel B Miesfeld; Myung-Soon Moon; Amy N Riesenberg; Ashley N Contreras; Rhett A Kovall; Nadean L Brown
Journal:  Sci Rep       Date:  2018-07-05       Impact factor: 4.379

6.  A Novel Reporter Mouse Uncovers Endogenous Brn3b Expression.

Authors:  Adam M Miltner; Yesica Mercado-Ayon; Simranjeet K Cheema; Pengfei Zhang; Robert J Zawadzki; Anna La Torre
Journal:  Int J Mol Sci       Date:  2019-06-14       Impact factor: 5.923

7.  Single cell transcriptomics reveals lineage trajectory of retinal ganglion cells in wild-type and Atoh7-null retinas.

Authors:  Fuguo Wu; Jonathan E Bard; Julien Kann; Donald Yergeau; Darshan Sapkota; Yichen Ge; Zihua Hu; Jie Wang; Tao Liu; Xiuqian Mu
Journal:  Nat Commun       Date:  2021-03-05       Impact factor: 14.919

Review 8.  The Genetic and Endoplasmic Reticulum-Mediated Molecular Mechanisms of Primary Open-Angle Glaucoma.

Authors:  Wioletta Rozpędek-Kamińska; Radosław Wojtczak; Jacek P Szaflik; Jerzy Szaflik; Ireneusz Majsterek
Journal:  Int J Mol Sci       Date:  2020-06-11       Impact factor: 5.923

9.  Effects of Adult Müller Cells and Their Conditioned Media on the Survival of Stem Cell-Derived Retinal Ganglion Cells.

Authors:  Xandra Pereiro; Adam M Miltner; Anna La Torre; Elena Vecino
Journal:  Cells       Date:  2020-07-22       Impact factor: 7.666

10.  The Atoh7 remote enhancer provides transcriptional robustness during retinal ganglion cell development.

Authors:  Joel B Miesfeld; Noor M Ghiasvand; Brennan Marsh-Armstrong; Nicholas Marsh-Armstrong; Eric B Miller; Pengfei Zhang; Suman K Manna; Robert J Zawadzki; Nadean L Brown; Tom Glaser
Journal:  Proc Natl Acad Sci U S A       Date:  2020-08-17       Impact factor: 11.205
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