Ravikant S Ganga1, Dipali Gundre2, Shivani Bansal3, Pankaj M Shirsat4, Pooja Prasad5, Rajiv S Desai6. 1. Department of Oral Pathology and Microbiology, Nair Hospital Dental College, Dr. A.L Nair Road, Mumbai Central, Mumbai 400008, India. Electronic address: drravikantganga@gmail.com. 2. Department of Oral Pathology and Microbiology, Nair Hospital Dental College, Dr. A.L Nair Road, Mumbai Central, Mumbai 400008, India. Electronic address: drdipali.gundre@gmail.com. 3. Department of Oral Pathology and Microbiology, Nair Hospital Dental College, Dr. A.L Nair Road, Mumbai Central, Mumbai 400008, India. Electronic address: bshivani2000@gmail.com. 4. Department of Oral Pathology and Microbiology, Nair Hospital Dental College, Dr. A.L Nair Road, Mumbai Central, Mumbai 400008, India. Electronic address: shirsat.pankaj@gmail.com. 5. Department of Oral Pathology and Microbiology, Nair Hospital Dental College, Dr. A.L Nair Road, Mumbai Central, Mumbai 400008, India. Electronic address: drprasadopath@gmail.com. 6. Department of Oral Pathology and Microbiology, Nair Hospital Dental College, Dr. A.L Nair Road, Mumbai Central, Mumbai 400008, India. Electronic address: nansrd@hotmail.com.
Abstract
OBJECTIVES: Conventional oral examination and biopsy are the only reliable methods for the early detection of oral cancer at present. Autofluorescence examination of oral tissues using the VELscope has been suggested as an adjunctive tool for cancer detection and diagnosis. The aim of our study was to evaluate the efficacy of the VELscope in recognizing dysplastic and/or neoplastic changes in oral mucosal lesions that were identified on conventional oral examination. MATERIALS AND METHODS: Two hundred patients with oral mucosal lesions were subjected to conventional oral examination followed by VELscope examination and their autofluorescence characteristics were compared with the histopathological diagnosis. The sensitivity, specificity, positive and negative predictive values of the VELscope examination was calculated. RESULTS: The VELscope examination showed sensitivity and specificity values of 76% (95% CI: 54.87-90.64%) and 66.29% (95% CI: 58.76-73.24%) respectively while the positive and negative predictive values were 24.36% (95% CI: 19.22-30.36%) and 95.08% (95% CI: 90.52-97.51%) respectively. CONCLUSION: The VELscope examination alone cannot provide a definitive diagnosis as to the presence of dysplastic tissue change. In spite of having a reasonable sensitivity, the high number of false-positive results limits its efficiency as an adjunct. However, a high negative predictive value can serve to alleviate patient anxiety regarding suspicious mucosal lesions in a general practice setting.
OBJECTIVES: Conventional oral examination and biopsy are the only reliable methods for the early detection of oral cancer at present. Autofluorescence examination of oral tissues using the VELscope has been suggested as an adjunctive tool for cancer detection and diagnosis. The aim of our study was to evaluate the efficacy of the VELscope in recognizing dysplastic and/or neoplastic changes in oral mucosal lesions that were identified on conventional oral examination. MATERIALS AND METHODS: Two hundred patients with oral mucosal lesions were subjected to conventional oral examination followed by VELscope examination and their autofluorescence characteristics were compared with the histopathological diagnosis. The sensitivity, specificity, positive and negative predictive values of the VELscope examination was calculated. RESULTS: The VELscope examination showed sensitivity and specificity values of 76% (95% CI: 54.87-90.64%) and 66.29% (95% CI: 58.76-73.24%) respectively while the positive and negative predictive values were 24.36% (95% CI: 19.22-30.36%) and 95.08% (95% CI: 90.52-97.51%) respectively. CONCLUSION: The VELscope examination alone cannot provide a definitive diagnosis as to the presence of dysplastic tissue change. In spite of having a reasonable sensitivity, the high number of false-positive results limits its efficiency as an adjunct. However, a high negative predictive value can serve to alleviate patientanxiety regarding suspicious mucosal lesions in a general practice setting.
Authors: Gary Peterson; Daniella Karassawa Zanoni; Marco Ardigo; Jocelyn C Migliacci; Snehal G Patel; Milind Rajadhyaksha Journal: Lasers Surg Med Date: 2019-05-08 Impact factor: 4.025
Authors: Nallan C S K Chaitanya; Sunanda Chavva; Elizabeth Surekha; Vedula Priyanka; Mule Akhila; Hari Kiran Ponnuru; Charan Kumar Reddy Journal: South Asian J Cancer Date: 2019 Oct-Dec
Authors: Marco Cicciù; Gabriele Cervino; Luca Fiorillo; Cesare D'Amico; Giacomo Oteri; Giuseppe Troiano; Khrystyna Zhurakivska; Lorenzo Lo Muzio; Alan Scott Herford; Salvatore Crimi; Alberto Bianchi; Dario Di Stasio; Rosario Rullo; Gregorio Laino; Luigi Laino Journal: Dent J (Basel) Date: 2019-09-04
Authors: Tanya Walsh; Richard Macey; Alexander R Kerr; Mark W Lingen; Graham R Ogden; Saman Warnakulasuriya Journal: Cochrane Database Syst Rev Date: 2021-07-20