Chi-Ching Chang1,2, Tzu-Min Lin2, Yu-Sheng Chang1,3, Wei-Sheng Chen4, Jau-Jiuan Sheu5,6, Yi-Hsuan Chen7, Jin-Hua Chen8. 1. a Division of Allergy, Immunology, and Rheumatology, Department of Internal Medicine, School of Medicine, College of Medicine , Taipei Medical University , Taipei , Taiwan. 2. b Division of Rheumatology, Immunology, and Allergy, Department of Internal Medicine , Taipei Medical University Hospital , Taipei , Taiwan. 3. c Division of Allergy, Immunology, and Rheumatology, Department of Internal Medicine , Shuang Ho Hospital, Taipei Medical University , New Taipei City , Taiwan. 4. d Division of Allergy, Immunology, and Rheumatology, Department of Internal Medicine , Taipei Veterans General Hospital, National Yang-Ming University , Taipei , Taiwan. 5. e Department of Neurology , Taipei Medical University Hospital , Taipei , Taiwan. 6. f Department of Neurology, School of Medicine, College of Medicine , Taipei Medical University , Taipei , Taiwan. 7. g Biostatistics Center, College of Management , Taipei Medical University , Taipei , Taiwan. 8. h Biostatistics Center and School of Health Care Administration, College of Management , Taipei Medical University , Taipei , Taiwan.
Abstract
BACKGROUNDS: In autoimmune rheumatic diseases (ARDs), the levels of inflammatory mediators are increased and microglia may be activated, resulting in an inflammatory state and the degeneration of dopaminergic neurons. We investigated the association between ARDs and Parkinson disease (PD). METHODS: We identified ARD patients through the Taiwan National Health Insurance Research Database from 2001 to 2012. From the general population, we randomly selected a comparison cohort that was frequency-matched by age (in 5-year increments), sex and index year. We analysed the risk of PD, stratified by sex, age and comorbidities, by using a Cox regression model. RESULTS: The risk of PD was 1.37 times greater in ARD patients than in controls after adjustment for age, sex, and comorbidities. ARD subgroups, such as the rheumatoid arthritis and Sjogren syndrome (SS) cohorts, were associated with a significantly higher risk of PD (adjusted hazard ratio [HR], 1.14; 95% confidence interval [CI], 1.03-1.2 and adjusted HR, 1.56; 95% CI, 1.35-1.79, respectively). Furthermore, primary and secondary SS patients had significantly higher risks of PD (adjusted HR, 1.58; 95% CI, 1.32-1.88 and adjusted HR, 1.53, 95% CI, 1.23-1.90, respectively). CONCLUSIONS: The risk of PD was significantly higher in the ARD patients. Prospective studies are needed to confirm whether ARDs indeed increase the risk of PD.
BACKGROUNDS: In autoimmune rheumatic diseases (ARDs), the levels of inflammatory mediators are increased and microglia may be activated, resulting in an inflammatory state and the degeneration of dopaminergic neurons. We investigated the association between ARDs and Parkinson disease (PD). METHODS: We identified ARD patients through the Taiwan National Health Insurance Research Database from 2001 to 2012. From the general population, we randomly selected a comparison cohort that was frequency-matched by age (in 5-year increments), sex and index year. We analysed the risk of PD, stratified by sex, age and comorbidities, by using a Cox regression model. RESULTS: The risk of PD was 1.37 times greater in ARD patients than in controls after adjustment for age, sex, and comorbidities. ARD subgroups, such as the rheumatoid arthritis and Sjogren syndrome (SS) cohorts, were associated with a significantly higher risk of PD (adjusted hazard ratio [HR], 1.14; 95% confidence interval [CI], 1.03-1.2 and adjusted HR, 1.56; 95% CI, 1.35-1.79, respectively). Furthermore, primary and secondary SS patients had significantly higher risks of PD (adjusted HR, 1.58; 95% CI, 1.32-1.88 and adjusted HR, 1.53, 95% CI, 1.23-1.90, respectively). CONCLUSIONS: The risk of PD was significantly higher in the ARD patients. Prospective studies are needed to confirm whether ARDs indeed increase the risk of PD.
Authors: Ruwani S Wijeyekoon; Deborah Kronenberg-Versteeg; Kirsten M Scott; Shaista Hayat; Wei-Li Kuan; Jonathan R Evans; David P Breen; Gemma Cummins; Joanne L Jones; Menna R Clatworthy; R Andres Floto; Roger A Barker; Caroline H Williams-Gray Journal: Brain Behav Immun Date: 2020-01-30 Impact factor: 19.227
Authors: Vanessa L Kronzer; Cynthia S Crowson; Jeffrey A Sparks; Elena Myasoedova; John Davis Journal: Arthritis Care Res (Hoboken) Date: 2021-02 Impact factor: 4.794