| Literature DB >> 29224104 |
Franck Mauvais-Jarvis1, Cedric Le May2, Joseph P Tiano3, Suhuan Liu4, Gamze Kilic-Berkmen5, Jun Ho Kim6.
Abstract
In rodent models of insulin-deficient diabetes, 17β-estradiol (E2) protects pancreatic insulin-producing β-cells against oxidative stress, amyloid polypeptide toxicity, gluco-lipotoxicity, and apoptosis. Three estrogen receptors (ERs)-ERα, ERβ, and the G protein-coupled ER (GPER)-have been identified in rodent and human β-cells. This chapter describes recent advances in our understanding of the role of ERs in islet β-cell function, nutrient homeostasis, survival from pro-apoptotic stimuli, and proliferation. We discuss why and how ERs represent potential therapeutic targets for the maintenance of functional β-cell mass.Entities:
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Year: 2017 PMID： 29224104 DOI： 10.1007/978-3-319-70178-3_18
Source DB: PubMed Journal: Adv Exp Med Biol ISSN： 0065-2598 Impact factor: 2.622