Seok Hui Kang1, Hyun Seok Lee2, Sukyung Lee3, Ji-Hyung Cho4, Jun Chul Kim4. 1. Division of Nephrology, Department of Internal Medicine, Yeungnam University Hospital, Daegu, Republic of Korea. 2. Department of Radiology, CHA Gumi Medical Center, CHA University, Gumi-si, Republic of Korea. 3. Division of Nephrology, Department of Internal Medicine, Semyung Christianity Hospital, Pohang-si, Republic of Korea. 4. Division of Nephrology, Department of Internal Medicine, CHA Gumi Medical Center, CHA University, Gumi-si, Republic of Korea.
Abstract
BACKGROUND/AIMS: Our study aims to evaluate the association between thigh muscle cross-sectional area (TMA) using computed tomography (CT), or appendicular skeletal muscle mass (ASM) using dual energy X-ray absorptiometry (DEXA), and physical performance levels in hemodialysis (HD) patients. METHODS: Patients were included if they were on HD for ≥6 months (n = 84). ASM and TMA were adjusted to body weight (BW, kg) or height2 (Ht2, m2). Each participant performed a short physical performance battery test (SPPB), a sit-to-stand for 30 second test (STS30), a 6-minute walk test (6-MWT), a timed up and go test (TUG), and hand grip strength (HGS) test. RESULTS: Correlation coefficients for SPPB, GS, 5STS, STS30, 6-MWT, and TUG were highest in TMA/BW. Results from partial correlation or linear regression analyses displayed similar trends to those derived from Pearson's correlation analyses. An increase in TMA/BW or TMA/Ht2 was associated with a decreased odds ratio of low SPPB, GS, or HGS in multivariate analyses. Indices using DEXA were associated with a decreased odds ratio of a low HGS only in multivariate analysis. CONCLUSION: TMA indices using CT may be more valuable in predicting physical performance or strength in HD patients.
BACKGROUND/AIMS: Our study aims to evaluate the association between thigh muscle cross-sectional area (TMA) using computed tomography (CT), or appendicular skeletal muscle mass (ASM) using dual energy X-ray absorptiometry (DEXA), and physical performance levels in hemodialysis (HD) patients. METHODS:Patients were included if they were on HD for ≥6 months (n = 84). ASM and TMA were adjusted to body weight (BW, kg) or height2 (Ht2, m2). Each participant performed a short physical performance battery test (SPPB), a sit-to-stand for 30 second test (STS30), a 6-minute walk test (6-MWT), a timed up and go test (TUG), and hand grip strength (HGS) test. RESULTS: Correlation coefficients for SPPB, GS, 5STS, STS30, 6-MWT, and TUG were highest in TMA/BW. Results from partial correlation or linear regression analyses displayed similar trends to those derived from Pearson's correlation analyses. An increase in TMA/BW or TMA/Ht2 was associated with a decreased odds ratio of low SPPB, GS, or HGS in multivariate analyses. Indices using DEXA were associated with a decreased odds ratio of a low HGS only in multivariate analysis. CONCLUSION:TMA indices using CT may be more valuable in predicting physical performance or strength in HDpatients.
Authors: Soo Jeong Choi; Min Sung Lee; Duk-Hee Kang; Gang Jee Ko; Hee-Sook Lim; Byung Chul Yu; Moo Yong Park; Jin Kuk Kim; Chul-Hee Kim; Seung Duk Hwang; Jun Chul Kim; Chang Won Won; Won Suk An Journal: Int J Environ Res Public Health Date: 2021-07-09 Impact factor: 3.390