BACKGROUND: and Purpose: Post-operative radiation therapy (PORT) is usually indicated for patients with breast cancer (BC) after neoadjuvant chemotherapy (NAC) and surgery. However, the optimal timing to initiation of PORT is currently unknown. MATERIAL AND METHODS: We retrospectively evaluated data from patients with BC who received PORT after NAC and surgery at our institution from 2008 to 2014. Patients were categorized into three groups according to the time between surgery and PORT: <8 weeks, 8-16 weeks and >16 weeks. RESULTS: A total of 581 patients were included; 74% had clinical stage III. Forty-three patients started PORT within 8 weeks, 354 between 8 and 16 weeks and 184 beyond 16 weeks from surgery. With a median follow-up of 32 months, initiation of PORT up to 8 weeks after surgery was associated with better disease-free survival (DFS) (<8 weeks versus 8-16 weeks: HR 0.33; 95% CI 0.13-0.81; p = 0.02; <8 weeks versus >16 weeks: HR 0.38; 95% CI 0.15-0.96; p = 0.04) and better overall survival (OS) (<8 weeks versus 8-16 weeks: HR 0.22; 95% CI 0.05-0.90; p = 0.036; <8 weeks versus >16 weeks: HR 0.28; 95% CI 0.07-1.15; p = 0.08). CONCLUSION: PORT started up to 8 weeks after surgery was associated with better DFS and OS in locally-advanced BC patients submitted to NAC. Our findings suggest that early initiation of PORT is critically important for these patients. However, the low numbers of patients and events in this study prevent us from drawing firm conclusions.
BACKGROUND: and Purpose: Post-operative radiation therapy (PORT) is usually indicated for patients with breast cancer (BC) after neoadjuvant chemotherapy (NAC) and surgery. However, the optimal timing to initiation of PORT is currently unknown. MATERIAL AND METHODS: We retrospectively evaluated data from patients with BC who received PORT after NAC and surgery at our institution from 2008 to 2014. Patients were categorized into three groups according to the time between surgery and PORT: <8 weeks, 8-16 weeks and >16 weeks. RESULTS: A total of 581 patients were included; 74% had clinical stage III. Forty-three patients started PORT within 8 weeks, 354 between 8 and 16 weeks and 184 beyond 16 weeks from surgery. With a median follow-up of 32 months, initiation of PORT up to 8 weeks after surgery was associated with better disease-free survival (DFS) (<8 weeks versus 8-16 weeks: HR 0.33; 95% CI 0.13-0.81; p = 0.02; <8 weeks versus >16 weeks: HR 0.38; 95% CI 0.15-0.96; p = 0.04) and better overall survival (OS) (<8 weeks versus 8-16 weeks: HR 0.22; 95% CI 0.05-0.90; p = 0.036; <8 weeks versus >16 weeks: HR 0.28; 95% CI 0.07-1.15; p = 0.08). CONCLUSION: PORT started up to 8 weeks after surgery was associated with better DFS and OS in locally-advanced BC patients submitted to NAC. Our findings suggest that early initiation of PORT is critically important for these patients. However, the low numbers of patients and events in this study prevent us from drawing firm conclusions.
Authors: G Luis Pendola; Roberto Elizalde; Pablo Sitic Vargas; José Caicedo Mallarino; Eduardo González; José Parada; Mauricio Camus; Ricardo Schwartz; Enrique Bargalló; Ruffo Freitas; Mauricio Magalhaes Costa; Vilmar Marques de Oliveira; Paula Escobar; Miguel Oller; Luis Fernando Viaña; Antonio Jurado Bambino; Gustavo Sarria; Francisco Terrier; Roger Corrales; Valeria Sanabria; Juan Carlos Rodríguez Agostini; Gonzalo Vargas Chacón; Víctor Manuel Pérez; Verónica Avilés; José Galarreta; Guillermo Laviña; Jorge Pérez Fuentes; Lía Bueso de Castellanos; Bolívar Arboleda Osorio; Herbert Castillo; Claudia Figueroa Journal: Ecancermedicalscience Date: 2020-10-06
Authors: Kennya Medeiros L de B Lima; Allan A Lima Pereira; Thiago B de Freitas; Saulo Brito Silva; Heloisa de Andrade Carvalho; Max S Mano; Gustavo Nader Marta Journal: Rep Pract Oncol Radiother Date: 2018-11-28
Authors: Nicole M Melchior; Darren B Sachs; Gabrielle Gauvin; Cecilia Chang; Chihsiung E Wang; Elin R Sigurdson; John M Daly; Allison A Aggon; Shelly B Hayes; Elias I Obeid; Richard J Bleicher Journal: Cancer Med Date: 2020-02-25 Impact factor: 4.452
Authors: Gustavo Nader Marta; Reem AlBeesh; Allan A Lima Pereira; Leandro Jonata Oliveira; Max S Mano; Tarek Hijal Journal: Breast Date: 2020-08-29 Impact factor: 4.380