Pingting Zhou1, Bo Li2, Bin Liu3, Tianrui Chen2, Jianru Xiao4. 1. Department of Oncology, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China. 2. Department of Orthopedic Oncology, Changzheng Hospital, Second Military Medical University, Shanghai, China. 3. Department of Hematology, Changhai Hospital, The Second Military Medical University, Shanghai, China. 4. Department of Orthopedic Oncology, Changzheng Hospital, Second Military Medical University, Shanghai, China. Electronic address: liboczspine@smmu.edu.cn.
Abstract
BACKGROUND: The alterations of lipid profile in cancer has been reported to be associated with cancer development. However, the prognostic value of serum lipid markers level in cancer is currently under debate. Here we performed a meta-analysis to investigate the prognostic significance of serum blood total cholesterol (TC), Triglycerides (TG), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) for cancer. METHODS: We systematically searched in PubMed and EMBASE for follow-up studies to evaluate the association between blood TC, TG, HDL-C, LDL-C and overall survival (OS) or disease-free survival (DFS) in patients with cancer. Pooled hazard ratio (HR) and 95% CIs were pooled using the random models. Subgroup and sensitivity analyses were also performed. RESULTS: Twenty-six studies including 24655 individuals were identified. For patients with higher TC before diagnosis, the summary HR were 0.82 (95% CI 0.75-0.90) for OS, 0.920 (95% CI, 0.849-0.997) for DFS. Patients with higher HDL-C had a 37% reduced risk of death compared with lower HDL-C (HR 0.63, 95%CI 0.47-0.86, P<0.001). As for DFS, patients with higher HDL-C level had the risk of disease relapse reduced by 35% (HR 0.65, 95% CI, 0.48-0.89, P<0.001) compared with patients with lower levels. CONCLUSIONS: After pooled analysis, only TC and HDL-C were significantly associated with cancer survival. Our findings demonstrate for the first time that serum TC and HDL-C was identified as a protective factor for overall survival in cancer patients.
BACKGROUND: The alterations of lipid profile in cancer has been reported to be associated with cancer development. However, the prognostic value of serum lipid markers level in cancer is currently under debate. Here we performed a meta-analysis to investigate the prognostic significance of serum blood total cholesterol (TC), Triglycerides (TG), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) for cancer. METHODS: We systematically searched in PubMed and EMBASE for follow-up studies to evaluate the association between blood TC, TG, HDL-C, LDL-C and overall survival (OS) or disease-free survival (DFS) in patients with cancer. Pooled hazard ratio (HR) and 95% CIs were pooled using the random models. Subgroup and sensitivity analyses were also performed. RESULTS: Twenty-six studies including 24655 individuals were identified. For patients with higher TC before diagnosis, the summary HR were 0.82 (95% CI 0.75-0.90) for OS, 0.920 (95% CI, 0.849-0.997) for DFS. Patients with higher HDL-C had a 37% reduced risk of death compared with lower HDL-C (HR 0.63, 95%CI 0.47-0.86, P<0.001). As for DFS, patients with higher HDL-C level had the risk of disease relapse reduced by 35% (HR 0.65, 95% CI, 0.48-0.89, P<0.001) compared with patients with lower levels. CONCLUSIONS: After pooled analysis, only TC and HDL-C were significantly associated with cancer survival. Our findings demonstrate for the first time that serum TC and HDL-C was identified as a protective factor for overall survival in cancerpatients.
Authors: Kosei Takagi; Piotr Domagala; Wojciech G Polak; Stefan Buettner; Bas P L Wijnhoven; Jan N M Ijzermans Journal: BMC Surg Date: 2019-09-05 Impact factor: 2.102